Citations
More filters
Journal ArticleDOI
The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias
A. M. Barrett,Valerie A. Cullum +1 more
TL;DR: Both isomers of propranolol were capable of preventing adrenaline‐induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (–)‐pro Pranolol was 0.09 ± 0.02 mg/kg whereas that of (+), which attenuated the responses to isoprenaline was 4.2 ± 1.2mg/kg.
Journal ArticleDOI
Selective blockade of adrenoceptive beta receptors in the heart
D. Dunlop,R. G. Shanks +1 more
Journal ArticleDOI
Clinical pharmacology of beta-receptor-blocking drugs.
TL;DR: This review does not cover the whole of this literature as it is particularly concerned with the effects of beta‐blocking drugs in man, and summarizes the adverse reactions so far reported with these drugs.
Journal ArticleDOI
The antiarrhythmic actions of beta adrenergic blocking agents
P. Somani,Bert K. B. Lum +1 more
TL;DR: Pronethalol and N-isopropyl- p -nitrophenyl-ethanolamine (INPEA) were found to antagonize the inotropic and chronotropic actions of epinephrine and isoproterenol as well as the vasodilator action of the latter, thus confirming the beta adrenergic blocking actions of the two agents.
References
More filters
Journal ArticleDOI
A study of the adrenotropic receptors
TL;DR: Experiments described in this paper indicate that although there are two kinds of adrenotropic receptors they cannot be classified simply as excitatory or inhibitory since each kind of receptor may have either action depending upon where it is found.
Journal ArticleDOI
Pharmacology of a new adrenergic beta-receptor-blocking compound (nethalide)
J.W. Black,J.S. Stephenson +1 more
Journal ArticleDOI
Use of Propranolol (Inderal) in Treatment of Hypertension
TL;DR: Patients' own general assessment of each treatment is based upon the whole 21-day periods and scored on a five-point scale in the following way: -1 worsening of the angina; + 1, + 2, and +3 indicating slight, moderate, and marked improvement respectively.
Related Papers (5)
The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias
A. M. Barrett,Valerie A. Cullum +1 more