Journal ArticleDOI
The role of cyanide liberation in the acute toxicity of aliphatic-nitriles
TLDR
The results suggested that the other nitriles examined here possess little, if any, acute toxicity in the absence of normal hepatic function and that these nit riles were activated by hepatic mechanisms to release cyanide which can account for their major acute toxic effects.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1981-07-01. It has received 96 citations till now. The article focuses on the topics: Sodium cyanide & Cyanide.read more
Citations
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Interaction of a series of nitriles with the alcohol-inducible isoform of P450: Computer analysis of structure—activity relationships
TL;DR: Correlations between molecular polarizability, excitation energy and biological activity are presented as a result of QSAR analysis on nitriles of varying rates of P4502E-mediated oxidative metabolism.
Toxicological profile for cyanide
TL;DR: This edition supersedes any previously released draft or final profile and succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described therein.
Book
Hydrogen cyanide and cyanides : human health aspects
TL;DR: This paper presents the first draft of a two-part monograph on “Self-consistency in the EMMARM: Towards a post-modern view”, which aims to provide a guide to the development of e-commerce and its applications in the rapidly changing environment.
Journal ArticleDOI
Studies on the mechanism of acute toxicity of nitriles in mice.
Hideji Tanii,Kazuo Hashimoto +1 more
TL;DR: All the test nitriles liberated cyanide ions both in vivo and in vitro, with the exception of benzonitrile, although the extent of liberation and the effect of carbon tetrachloride (CCl4) pretreatment on the mortality of animals differed amongNitriles.
References
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Book
Clinical Toxicology of Commercial Products
TL;DR: The toxicology of commercial products and its applications are studied in the context of food safety, cosmetics and personal care products.
Journal ArticleDOI
Appendix—Spectrum of horse-heart cytochrome c
E. Margoliash,Nehamah Frohwirt +1 more
Patent
Organic nitrogen compounds
TL;DR: In this article, a process for the preparation of quaternary ammonium compounds is described. But this process is restricted to a single type of compound and is not suitable for other compounds.
Journal ArticleDOI
A study of the kinetics of the oxidation of cytochrome c by cytochrome c oxidase.
Lucile Smith,Helen Conrad +1 more
TL;DR: The results can best be explained by assuming an inhibitory effect of cytochrome c (either oxidized or reduced) on the reaction, which can explain a number of discrepancies previously apparent in studies of the kinetics of cy tochrome c oxidase activity.