The role of the non-depolarizing drugs in the prevention of suxamethonium bradycardia
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Evidence has been presented to show that a second dose of suxamethonium is capable of producing a severe bradycardia in man, which may be effectively prevented by the prior administration of certain non-depolarizing muscle relaxants namely tubocurarine, alcuronium, c -toxiferine and pancuronium.Abstract:
SUMMARY Evidence has been presented to show that a second dose of suxamethonium is capable of producing a severe bradycardia in man. This response may be effectively prevented by the prior administration of certain non-depolarizing muscle relaxants namely tubocurarine, alcuronium, c -toxiferine and pancuronium in quantities of one-quarter or less of their muscle relaxant level. It is suggested that suxamethonium causes altered cardiac rhythm by stimulation of afferent vagal receptors, which action may be blocked by tubocurarine and similar drugs.read more
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References
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Journal ArticleDOI
Succinylcholine danger in the burned patient.
Journal ArticleDOI
The excitant action of acetylcholine and other substances on cutaneous sensory pathways and its prevention by hexamethonium and D-tubocurarine.
W. W. Douglas,J. A. B. Gray +1 more
TL;DR: The experiments described in this paper show that a-lobeline, like acetylcholine and nicotine, can excite a discharge in sensory fibres from the skin; and that hexamethonium and D-tubocurarine prevent the excitant effect of this group of drugs without influencing the normal touch response.
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Observations on the excitation by acetylcholine and by pressure of sensory receptors in the cat's carotid sinus
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Effect of suxamethonium on cardiac rhythm.
TL;DR: Patch tests must, of course, be postponed until the dermatitis has healed, and should always be applied to skin which has not been involved in the attack, and the interscapular region is often suitable.
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