The value of adenosine deaminase (ADA) determination in the diagnosis of tuberculous ascites
Brant Cq,Mario R. Silva Jr.,Erica P. Macedo,Claudio Vasconcelos,Natalina Tamaki,M. Lucia G. Ferraz +5 more
TLDR
It is concluded that ADA determination in ascitic fluid is a useful and reliable screening test for diagnosing tuberculous ascites and values of ADA higher than 31 U/l indicate more invasive methods to confirm the diagnosis of tuberculosis.Abstract:
Com o objetivo de avaliar o papel da determinacao da atividade da enzima adenosina deaminase (ADA) no diagnostico da peritonite tuberculosa, foram estudados 44 pacientes. De acordo com os resultados das determinacoes bioquimicas, citologicas, histopatologicas e microbiologicas, os pacientes foram divididos nos seguintes grupos: G1 - ascite tuberculosa (n = 8); G2 - neoplasica (n = 13), G3 - peritonite bacteriana espontânea (n = 6), G4 -ascite pancreatica (n = 2), G5 - miscelânea (n = 15). A concentracao de ADA no grupo de pacientes com peritonite tuberculosa foi de 133.50 ± 24.74 U/l, significantemente mais elevada que nos outros grupos (G2 = 41.85 ± 52.07; G3 = 10.63 ± 5.87; G4 = 18.00 ± 7.07; G5 = 11.23 ± 7.66). Com um limite de corte de 31 U/l, a sensibilidade, especificidade, valor preditivo positivo e valor preditivo negativo para diagnostico de tuberculose foram, respectivamente 100%, 92%, 72% e 100%. Valores de ADA tao elevados quanto na tuberculose so foram encontrados nas ascites neoplasicas causadas por linfomas. Com base nestes achados, consideramos que a determinacao de ADA deve ser utilizada como um teste de triagem no diagnostico diferencial das ascites. Valores de ADA acima de 31 U/l indicam a necessidade de testes invasivos (laparoscopia e/ou biopsia peritonial, para confirmacao diagnostica).read more
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A systematic review of rapid diagnostic tests for the detection of tuberculosis infection.
Jacqueline Dinnes,Jonathan J Deeks,Heinke Kunst,Andrea L. Gibson,E Cummins,Norman Waugh,Francis Drobniewski,Ajit Lalvani +7 more
TL;DR: High specificity estimates suggest that NAAT tests should be the first-line test for ruling in TB meningitis, but that they need to be combined with the result of other tests in order to rule out disease.
Value of Adenosine Deaminase (ADA) in Ascitic Fluid for the Diagnosis of Tuberculous Peritonitis
TL;DR: This study supports the proposition that ADA determination is a fast and discriminating test for diagnosing PTB with an optimal cut-off value of 39 IU/L.
Journal ArticleDOI
Value of adenosine deaminase (ADA) in ascitic fluid for the diagnosis of tuberculous peritonitis: a meta-analysis.
Arnoldo Riquelme,Mario Calvo,Felipe Salech,Sebastián Valderrama,Alejandro Pattillo,Marco Arellano,Marco Arrese,Alejandro Soza,Paola Viviani,Luz María Letelier +9 more
TL;DR: In this article, a systematic review was conducted to determine the usefulness of ADA levels in ascitic fluid as a diagnostic test for peritoneal tuberculosis (PTB) and define the best cutoff point.
Journal ArticleDOI
Intra-abdominal and gastrointestinal tuberculosis.
TL;DR: The benefits and potential pitfalls of diagnostic methods are concentrated on and the nonspecific features of the disease result in difficulty in establishing a diagnosis.
Journal ArticleDOI
Diagnostic value of adenosine deaminase in ascites for tuberculosis ascites: a meta-analysis
TL;DR: The results suggest that ADA in the ascites can be a sensitive and specific target and a critical criterion for the diagnosis of TB ascites.
References
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Book
Methods of Enzymatic Analysis
TL;DR: Methods of enzymatic analysis, Methods of enzymes analysis, the authors, Methods of enzyme analysis, enzymatics, methods of enzymes, and methods of analysis, method of enzymes.
Journal ArticleDOI
Tuberculous peritonitis. An evaluation of pathogenetic mechanisms, diagnostic procedures and therapeutic measures.
Journal Article
Value of adenosine deaminase estimation in the diagnosis of tuberculous ascites.
TL;DR: Estimation of adenosine deaminase in ascitic fluid is an easy and reliable method for diagnosing tuberculous ascites and its sensitivity, specificity, positive and negative predictive value, and the overall diagnostic accuracy were 100%, 96.6%, 95%, 100%, and 98%, respectively.
Journal ArticleDOI
Diagnostic value of ascites adenosine deaminase in tuberculous peritonitis
TL;DR: The findings suggest that the ascitic fluid adenosine deaminase activity may be used to identify patients in whom the diagnosis of abdominal tuberculosis must be pursued.