Showing papers in "Hepatology in 1988"

TL;DR: The stimulation of the renin‐angiotensin‐aldosterone system, vasopressin release and sympathetic nervous system associated with cirrhosis is not consonant with primary volume expansion, and favors the “overflow” hypothesis.

TL;DR: In addition to age factor, the extent, severity, duration, frequency and etiology of the hepatic lobular alterations are important factors for the development of cirrhosis in patients with chronic type B hepatitis.

TL;DR: Endotoxin concentrations were measured in the portal, hepatic and peripheral venous blood of two groups of patients with cirrhosis using a limulus‐based chromogenic assay using an order of magnitude greater than previously possible by gelation studies.

TL;DR: It is concluded that spontaneous bacterial peritonitis frequently recurs in cirrhosis, particularly in patients with severe liver failure or low protein concentration in ascitic fluid, and that the survival of cirrhotics who recover from a first episode of spontaneous bacterialperitonitis is very short.

TL;DR: A prospective study identified 45 patients with malignancy‐related ascites among 448 ascites patients and identified five subgroups based on the pathophysiology of ascites formation that had a distinctive ascitic fluid analysis.

TL;DR: The development of the intrahepatic bile ducts in man was studied using an immunohistochemical technique on 56 liver specimens ranging in age from 6 weeks of gestation to 8 months after birth.

TL;DR: Results indicated a marked deficiency in the metabolism of S‐adenosyl‐L‐methionine in cirrhosis.

TL;DR: The results indicate that intraperitoneal transplantation of microcarrier‐attached hepatocytes prior to 90% partial hepatectomy in rats provides acute metabolic support resulting in improved survival.

TL;DR: A new autoantibody was detected by immunoprecipitation in the serum of 21 patients with chronic active hepatitis and was considered a second marker of chronic active liver disease associated with anti‐LKM1 (anti‐LkM1 chronicactive hepatitis) or autoimmune Chronic active hepatitis Type 2.

TL;DR: Patients with deficient ascitic fluid opsonic activity are predisposed to spontaneous bacterial peritonitis.

TL;DR: Fifty‐one asymptomatic Chinese hepatitis B surface antigen (HBsAg) carrier children were prospectively followed for up to 4 years to determine the natural evolution of clinical, biochemical and virological features during the early phase of chronic hepatitis B virus infection.

TL;DR: The appearance of transitional cells was associated with a corresponding decrease in the number of lipocytes, supporting the hypothesis that transitional cells were derived from lipocytes.

TL;DR: It is suggested that γ‐interferon produced by T lymphocytes that infiltrate the liver during the course of chronic hepatitis induces Class II major histocompatibility complex antigen expression and may endow the hepatocytes with the capacity to perform accessory (antigen‐presenting) cell functions.

TL;DR: The study demonstrates a direct correlation between high ATP content and good posttransplant outcome and shows no significant differences in AMP, xanthine or hypoxanthine for the two groups.

TL;DR: The hypothesis that in human cirrhotic liver there is a marked reduction in the rate of synthesis and utilization of S‐adenosyl‐L‐methionine is supported.

TL;DR: It is shown that liver histology from patients with graft‐versus‐host disease could be distinguished from other common liver diseases and liver biopsies from patients without graft-versus-host disease confirmed this hypothesis.

TL;DR: The relationships between portal pressure, liver function and clinical variables on one hand and development of variceal hemorrhage and death on the other were investigated in 58 men with newly diagnosed alcoholic cirrhosis.

TL;DR: A prospective, randomized trial to see whether β‐blockers could also prevent the first hemorrhage in patients who survived episodes of variceal rupture.

TL;DR: Hepatocytes, prepared from normal adult rat liver, were seeded onto a collagen substratum and cultured alone or in the presence of rat liver endothelial cells. as discussed by the authors showed that when hepatocytes were cultured alone in a hormonally defined serum-free medium, decreased albumin production and rapid morphological deterioration of bile canaliculi structures and gap junctions occurred within 4 to 5 days.

TL;DR: Results indicate that the plasma levels of immunoreactive atrial natriuretic factor are increased in patients with cirrhosis and ascites, and that this is due to an increased release and not to an impaired splanchnic degradation of the peptide.

TL;DR: Doubts are raised as to the reliability of anti‐HBc (Corzyme, Abbott Laboratories, North Chicago, Ill.) as a single screening test for hepatitis B infection prior to vaccination and it is suggested that subjects with isolated anti-HBc, in particular those with low anti‐ HBc titers, be included in vaccination programs.

TL;DR: The effects of tetracycline on the mitochondrial oxidation of fatty acids in mice and in man are determined.

TL;DR: The mechanism of nitrofurantoin‐induced hepatic injury seems to be immunoallergic and Histology showed mainly necrosis, varying from spotty to massive, in the acute cases and a pattern consistent with chronic active hepatitis in the chronic cases.

TL;DR: The prognosis of anti‐HBe‐positive patients with chronic hepatitis B is poor, as 54% of the cases developed cirrhosis during a mean histologic follow‐up period of 4.5 years, mainly in association with hepatitis delta virus infection or continuing hepatitis B virus replication.

TL;DR: It is indicated that serum hyaluronate may be a sensitive marker for progressive liver damage in primary biliary cirrhosis and of potential value for monitoring liver function during clinical management of the condition.

TL;DR: The role of epidermal growth factor on liver regeneration after partial hepatectomy in rats was investigated and it was found that oral or s.c. administration of epidesis growth factor had no effect on liver Regeneration, whereas epiderm growth factor enhanced the effect of insulin and glucagon on liver regenerate.

TL;DR: Like the rat peritoneal macrophage, the isolated Kupffer cell is capable of processing and releasing iron acquired by phagocytosis of immunosensitized homologous red blood cells.

TL;DR: Part correlation analysis confirmed that age, when entered in a multiple regression already containing body weight and estimated liver volume as independent variables, had a significant effect on liver function, whereas no significant independent effect of liver volume was present.