Journal ArticleDOI
Thymus dysgenesis in nude (nu nu) mice
E. M. Pantelouris,Janet Hair +1 more
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The thymic rudiment in mice homozygous for the recessive mutation nude (nu) has been compared to the normal at two stages: the 14– to 15-day foetus and the 1– to 2-day-old young.Abstract:
The thymic rudiment in mice homozygous for the recessive mutation nude (nu) has been compared to the normal at two stages: the 14– to 15-day foetus and the 1– to 2-day-old young. In the former, the normal thymus already comprises two adjacent lobes but in the nude it is represented by a pair of thin strands of tissue, each with a narrow central lumen. In further development these strands become thicker and vesiculated. They progress no further and are found in the 1– to 2-day young as small vestiges that are never populated with lymphoid cells. The thyroid, parathyroids and mandible of homozygous nude mice are normal, indicating that the complex of structures derived from the third branchial arch is not affected as a whole.read more
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Human tumor cells in vitro
TL;DR: The strategy of a Search for Viral Involvement in Human Cancer and Helper Activity for the Defective Friend Leukemia Virus in Human Malignant Cell Cultures are considered.
Journal ArticleDOI
Development of thymus, parathyroids, and ultimo-branchial bodies in NMRI and nude mice
TL;DR: Morphometric analysis shows that the volume of the parathyroids is the same in both strains of mice at each stage of development; nor does their microscopic appearance differ; thus, mutation in the Nude mouse does not affect the development of theParathyroid from the third pouch, even though the first anomalies in thedevelopment of the thymus are observed at the precise moment at which the par Kathyroid primordium appears.
Journal ArticleDOI
Surface antigenic markers for distinguishing T and B lymphocytes in mice.
TL;DR: The finding that the surfaces of these two types of lymphocytes are antigenicaJly distinguishable, at least in the mouse, has provided a useful means of making this distinction, and surface antigenic markers on lymphocytes have become powerful and popular tools in immunology.
Journal ArticleDOI
Autonomic nervous system innervation of thymic-related lymphoid tissue in wildtype and nude mice.
Karen Bulloch,William Pomerantz +1 more
TL;DR: A study was undertaken to determine the source and terminal distribution of the autonomic nervous system innervation of lymphoid tissue in the mediastinum of male and female B10 and Balb/c wildtype and syngeneic nude (nu/nu) mice and to discuss nervous: immune system interactions.
Journal ArticleDOI
Abnormal development of the thymus in "nude" mice
TL;DR: These experiments show that nude mice suffer from a defect of the epithelial portion of the thymus rather than of the precursors of thymocytes, and can be repopulated with nude bone marrow.
References
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Journal ArticleDOI
‘Nude’, a new hairless gene with pleiotropic effects in the mouse
TL;DR: Nude is a new recessive gene causing hairlessness in the mouse and is linked to rex and trembler in linkage group VII, which causes reduced body growth rate, very low fertility and a liver disease causing death.
Journal ArticleDOI
Absence of Thymus in a Mouse Mutant
TL;DR: Part of the mouse mutant “nude” syndrome was sulphydryl group deficiency and abnormal keratinization of hair follicles, and necrosis of the liver, associated with Toxoplasma gondii infection.
Journal Article
The lymphoid tissues in mice with congenital aplasia of the thymus
TL;DR: The nu nu mice are potentially important as experimental tools in delineating the role of the thymus in the development of the lymphoid system, and as an experimental model of thymic alymphoplasia in the human.