Journal ArticleDOI
Thyroid hormone and tricyclic antidepressants in resistant depressions.
TLDR
The author concludes that thyroid hormone potentiates the effects of the tricyclic antidepressants to some extent, but he suggests the need for further study in this area.Abstract:
The author conducted a study of 25 retarded depressed patients who previously responded inadequately to tricyclic antidepressants. Continuing the group on antidepressants, he also administered thyroid hormone. Fourteen showed an excellent response to the combination. He concludes that thyroid hormone potentiates the effects of the tricyclic antidepressants to some extent, but he suggests the need for further study in this area.read more
Citations
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Journal ArticleDOI
Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment: Implications for the Etiology and Therapy of Depression
TL;DR: The effects of long-term antidepressant treatment on biogenic amine metabolism and on various indexes of presynaptic and postsynaptic receptor function are evaluated to provide support for hypotheses of amine receptor abnormalities in depression and indicate the need for expanded studies ofAmine receptor function in patients.
Journal ArticleDOI
Effects of thyrotropin-releasing hormone in depression.
TL;DR: Ten euthyroid women with unipolar depression were treated with a single injection of thyrotropin-releasing hormone (T.R.H.) and a single injections of saline in a double-blind, crossover comparison to cause a prompt, brief improvement in depression.
Journal ArticleDOI
Triiodothyronine Augmentation in the Treatment of Refractory Depression: A Meta-analysis
TL;DR: Triiodothyronine augmentation may be an effective empirical method of increasing response rates and decreasing depression severity scores in a subgroup of patients with depression refractory to tricyclic antidepressant therapy, but the total number of patients randomized was small, and additional placebo-controlled data are required for a definitive verdict.
Journal ArticleDOI
A Hypothesis of Thyroid-Catecholamine-Receptor Interaction: Its Relevance to Affective Illness
TL;DR: Evidence suggests that the modulation by thyroid hormones of the beta-adrenergic receptor response to catecholamines may contribute to these effects of depression and mania.
Journal ArticleDOI
A Placebo-Controlled Comparison of Lithium and Triiodothyronine Augmentation of Tricyclic Antidepressants in Unipolar Refractory Depression
TL;DR: This study suggests that both lithium and liothyronine may be considered as alternatives in augmenting antidepressant response in patients who do not respond to treatment with a tricyclic antidepressant.
References
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Journal ArticleDOI
Enhancement of Imipramine Antidepressant Activity by Thyroid Hormone
TL;DR: Twenty euthyroid patients with retarded depression were studied to determine the possible role of alterations in thyroid function in the etiology and treatment of depression, and T3 was physiologically active, altering protein-bound iodine values and accelerating ankle reflex time.