Journal ArticleDOI
Toxicity of chronic dichloroacetate.
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This article is published in The New England Journal of Medicine.The article was published on 1979-02-15. It has received 53 citations till now. The article focuses on the topics: Toxicity.read more
Citations
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Journal ArticleDOI
The pharmacology of dichloroacetate.
TL;DR: Despite its potential toxicity and limited clinical experience, DCA and its derivatives may prove to be useful in probing regulatory aspects of intermediary metabolism and in the acute or chronic treatment of several metabolic disorders.
Journal ArticleDOI
Lactate homeostasis and lactic acidosis.
TL;DR: The roles of changes in cellular redox, interorgan lactate flux and balance, and quantitative aspects of lactate metabolism in the pathogenesis of lactic acidosis are discussed.
Journal ArticleDOI
The metabolic effects of dichloroacetate
TL;DR: Dichloroacetate has been tried experimentally in treatment of diabetes, hypercholesterolemia, and hyperlactatemia, but it has neurotoxicity, can cause cataracts, and may be mutagenic.
Journal ArticleDOI
Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?
TL;DR: Inhibition of PDKs could be an attractive therapeutic approach for the development of anti-cancer drugs because of their role as regulator of PDC that catalyzes the oxidative decarboxylation of pyruvate in mitochondrion.
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Metabolic acidosis in the intensive care unit
TL;DR: A logical approach to metabolic acidosis is presented, which demonstrates the importance of knowing the pathological mechanisms underlying the generation of protons in order to establish an acceptable treatment strategy.
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Journal ArticleDOI
Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia.
TL;DR: Dichloroacetate significantly reduced fasting hyperglycemia an average of 24 per cent from base line and produced marked, concomitant falls in plasma lactate and alanine, whereas excretion and renal clearance fell.