Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.
P Borgeat,B Samuelsson +1 more
TLDR
A new metabolite of arachidonic acid, 5-D-(S),12- D-(R)-dihydroxy-6,8,10,14-eicosatetraenoic acid, was found upon incubation of the fatty acid with a suspension of rabbit peritoneal polymorphonuclear leukocytes collected 4 h after injection of glycogen into theperitoneal cavity.About:
This article is published in Journal of Biological Chemistry.The article was published on 1979-04-25 and is currently open access. It has received 608 citations till now. The article focuses on the topics: Arachidonic acid & Fatty acid.read more
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Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation
TL;DR: Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions.
Journal ArticleDOI
Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes
TL;DR: The chemokinetic and aggregating activities released from rat and human PMNs exposed to ionophore A23187 are not due to the release of mono-HETEs but to that of 5,12-di- HETE (leukotriene B), which is active over the concentration range 10 pg ml−1 to 5 ng ml-1.
Journal ArticleDOI
Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases.
TL;DR: Since the chemical characterization of the slow-reacting substance of anaphylaxis as several cysteinyl leukotrienes and the identification and biochemical assessment of the enzymes in the 5-lipoxygenase pathway, the products of this pathway have been implicated in a much broader variety of functions.
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Leukotriene C: a slow-reacting substance from murine mastocytoma cells.
TL;DR: In this paper, the slow-reacting substance (SRS) that caused guinea pig ileum to contract was identified as a cysteine-containing derivative of 5-hydroxy-7,9,11,14-icosatetraenoic acid.
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Enhanced Synthesis of Leukotriene B4 by Colonic Mucosa in Inflammatory Bowel Disease
TL;DR: The presence of significant amounts of leukotriene B4 in colonic mucosa in patients with inflammatory bowel disease, combined with the known biologic effects of leucotrienes B4, suggests that it may be an important mediator of inflammation in inflammatory bowel Disease.
References
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Plaque formation and isolation of pure lines with poliomyelitis viruses.
Renato Dulbecco,Marguerite Vogt +1 more
TL;DR: Pure virus lines were established by isolating the virus population produced in single plaques, which had the same morphological, serological, and pathogenic properties as the parent strain.
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An extension of the 51cr-release assay for the estimation of mouse cytotoxins.
TL;DR: The usefulness of the method is shown by demonstrating its success with suspensions of mouse spleen cells and with a hemorrhagic ascites sarcoma.
Journal ArticleDOI
Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases.
TL;DR: Addition of arachidonic acid and homo-gamma-linolenic acid to a suspension of rabbit peritoneal neutrophils led to the synthesis of 5-L-hydroxy-6,8,11,14-eicosatetraenoic acid and 8- L-hydroxyl group alpha to a pair of conjugated cis/trans double bonds suggested that they were formed by action of lipoxygenease(s).
Journal ArticleDOI
Phagocytin: a bactericidal substance from polymorphonuclear leucocytes.
TL;DR: Although phagocytin is reasonably stable at temperatures of 65°C.
Journal ArticleDOI
Steric analysis of hydroperoxides formed by lipoxygenase oxygenation of linoleic acid.
TL;DR: Gas-liquid chromatography allowed separation of the diastereoisomeric derivatives and thus provided a sensitive means for determination of the absolute configuration of the parent unsaturated hydroxy ester.
Related Papers (5)
Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes
Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds.
P Borgeat,B Samuelsson +1 more