Journal ArticleDOI
Ultrastructural and morphometric study of the human heart muscle cell in acute coronary insufficiency
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TLDR
It is postulated that in sublethal ischemia definite ultrastructural modifications of the heart muscle cells are associated with a decrease in the number of mitochondria per unit volume of cytoplasm.About:
This article is published in Human Pathology.The article was published on 1979-11-01. It has received 14 citations till now. The article focuses on the topics: Myocyte & Ischemia.read more
Citations
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Journal ArticleDOI
Ultrastructural morphometric analysis of myocardium from dogs, rats, hamsters, mice, and from human hearts.
J Schaper,E Meiser,G Stämmler +2 more
TL;DR: It is concluded that each mammalian species is characterized by a very typical quantitative composition of the myocardium, as well as the morphological correlate of the differing functional capacity of hearts from different species.
Journal ArticleDOI
Recurrent sustained ventricular tachycardia: structure and ultrastructure of subendocardial regions in which tachycardia originates.
TL;DR: The abnormal structure and arrangement of the surviving cardiac fibers in the endocardium may cause the abnormal electrophysiologic function that results in ventricular tachycardia.
Journal ArticleDOI
Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation
Dalit May,Dan Gilon,Valentin Djonov,Ahuva Itin,Alon Lazarus,Oren Gordon,Christian Rosenberger,Eli Keshet +7 more
TL;DR: A transgenic mouse system for conditional induction of long-term hibernation and a system to rescue hibernating cardiomyocytes at will are developed and it is shown that VEGF is indispensable for adjusting the coronary vasculature to match increased oxygen consumption and exploited to generate a hypoperfused heart.
Journal ArticleDOI
A TAT–Frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's ataxia mouse model
Piyush M. Vyas,Wendy J. Tomamichel,P. Melanie Pride,Clifford M. Babbey,Qiujuan Wang,Jennifer Mercier,E. Martin,R. Mark Payne +7 more
TL;DR: Results show that a cell-penetrant peptide is capable of delivering a functional mitochondrial protein in vivo to rescue a very severe disease phenotype, and present the possibility of TAT-FXN as a protein replacement therapy.
Journal ArticleDOI
Mitochondrial and mitochondrial-independent pathways of myocardial cell death during ischaemia and reperfusion injury.
Sean M. Davidson,Adriana Adameova,Lucio Barile,Hector A. Cabrera-Fuentes,Antigone Lazou,Pasquale Pagliaro,Kåre-Olav Stensløkken,David Garcia-Dorado,David Garcia-Dorado +8 more
TL;DR: Both mitochondrial and mitochondrial‐independent pathways of the major modes of cell death, their role in IR injury and their potential to be targeted as part of a cardioprotective strategy are discussed.
References
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Journal ArticleDOI
THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY
TL;DR: The stain reported here differs from previous alkaline lead stains in that the chelating agent, citrate, is in sufficient excess to sequester all lead present, and is less likely to contaminate sections.
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Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.
TL;DR: A postfixation in osmium tetroxide, even after long periods of storage, developed an image that—notable in the case of glutaraldehyde—was largely indistinguishable from that of tissues fixed under optimal conditions with osmia tetroxides alone.
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CORRELATED MORPHOMETRIC AND BIOCHEMICAL STUDIES ON THE LIVER CELL I. Morphometric Model, Stereologic Methods, and Normal Morphometric Data for Rat Liver
TL;DR: Stereologic methods which allow efficient and reliable quantitative evaluation of sectioned liver tissue are presented and validity and applicability of the method are discussed, and the data are compared with available information from other studies.
Journal ArticleDOI
Quantitative electron microscopic description of heart muscle cells. Application to normal, hypertrophied and thyroxin-stimulated hearts.
Ernest Page,L.P. McCallister +1 more
TL;DR: Application of mathematical techniques to the study of experimental left ventricular hypertrophy and thyroxin-stimulated growth of myocardial cells has confirmed and extended the results of quantitative measurements on electron micrographs, suggesting that the approaches described can form the basis of a quantitative electron microscopic and microchemical pathology of heart muscle.
Journal Article
Fine structural changes in myocardial ischemic injury.
Jennings Rb,Baum Jh,Herdson Pb +2 more
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