Ultrastructural study of Mycoplasma pneumoniae in organ culture.
M H Wilson,A M Collier +1 more
TLDR
The ultrastructure of Mycoplasma pneumoniae M129 was studied by using specialized staining methods for thin-section transmission electron microscopy and found that M. pneumoniae was enveloped in an extracellular mucoprotein layer that was especially concentrated around its terminal structure.Abstract:
The ultrastructure of Mycoplasma pneumoniae M129 was studied by using specialized staining methods for thin-section transmission electron microscopy. Nucleic acid was shown in the cytoplasmic granules and fibrillar material in the nuclear region. The central filament of the highly structured tip contained basic protein. With one method of fixation, parallel filaments were seen in the central core. M. pneumoniae was enveloped in an extracellular mucoprotein layer that was especially concentrated around its terminal structure.read more
Citations
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Mycoplasma pneumoniae and Its Role as a Human Pathogen
TL;DR: Mycoplasma pneumoniae is a unique bacterium that does not always receive the attention it merits considering the number of illnesses it causes and the degree of morbidity associated with it in both children and adults.
Journal ArticleDOI
A newly discovered mycoplasma in the human urogenital tract.
TL;DR: Although the data are insufficient to implicate the new mycoplasmas in human disease, the fact that they are unique, extremely fastidious, and have adherence properties, has stimulated efforts to assess their pathogenicity and possible role in human urogenital disease.
Journal ArticleDOI
IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection.
TL;DR: It is demonstrated that IL-17/IL-17F production is IL-23-dependent in an acute Mp infection, and contributes to neutrophil recruitment and activity in the lung defense against the infection.
Journal ArticleDOI
Molecular basis for cytadsorption of Mycoplasma pneumoniae.
TL;DR: Characterization of HA+ virulent and HA- avirulent strains of M. pneumoniae by one- and two-dimensional polyacrylamide gel electrophoresis suggests that identified groups of mycoplasma proteins regulate the physical arrangement of P1 and the ultrastructure of the terminus, thus influencing adherence to the respiratory epithelium and virulence.
Journal ArticleDOI
Mycoplasma pneumoniae infection: role of a surface protein in the attachment organelle
Ping C. Hu,Roger M. Cole,Y. S. Huang,Judith A. Graham,D. E. Gardner,Albert M. Collier,Wallace A. Clyde +6 more
TL;DR: Attachment of Mycoplasma pneumoniae to host cell by means of a specialized terminus initiates infection and monoclonal antibodies to a surface protein (Pl) inhibit this process, and react with a region of the tip covered with peplomer-like particles.
References
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