Journal ArticleDOI
Umpolung Strategy for the Synthesis of 2‐Deoxy‐C‐aryl Glycosides: A Serendipitous, Efficient Route for C‐Furanoside Analogues.
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TLDR
In this paper, the authors describe a synthetic route using an umpolung strategy, which has not been explored till date, which led to a versatile intermediate aryl ketone 10 which has paved the way for two important classes of C-glycosides, viz., C-alkyl furanosides 12 and methyl 2-deoxy-C-aryl pyranosides 14.Abstract:
2-Deoxy-C-aryl glycosides are potential synthetic targets as they form a very vital moiety of several biologically active natural products. This paper describes a synthetic route using an umpolung strategy, which has not been explored till date. Our synthetic endeavor led to a versatile intermediate aryl ketone 10, which has paved the way for two important classes of C-glycosides, viz., C-alkyl furanosides 12 and methyl 2-deoxy-C-aryl pyranosides 14.read more
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Dissertation
Structure design and synthesis of Novel Aryl C-Glycosides as PTP-1B or GP inhibitors and their bioactivities
TL;DR: Protein tyrosine phosphatase 1B (PTP 1B) and glycogen phosphorylase (GP) are new therapeutic targets of type 2 diabetes and obesity and preliminary results of in vitro bioactivities test showed that some target compounds exhibited interesting activities which could be further studied.
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Journal ArticleDOI
Umpolung strategy for the synthesis of 2-deoxy-C-aryl glycosides: a serendipitous, efficient route for C-furanoside analogues.
TL;DR: A synthetic route using an umpolung strategy led to a versatile intermediate aryl ketone 10, which has paved the way for two important classes of C-glycosides, viz., C-alkyl furanosides 12 and methyl 2-deoxy-C-aryl pyranosides 14.