Open AccessJournal Article
Unstable chromosome aberrations in peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy.
Simey de Souza Leão Pereira Magnata,Isvania Serafim,Julia Netto,Polion Gomes,André Maciel Netto,Ademir Amaral +5 more
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TLDR
Blood samples from 5 patients, with cervical uterine cancer, were analyzed by conventional cytogenetic in order to correlate the frequency of chromosome aberrations in lymphocytes with the dose absorbed by the patient, as a result of radiotherapy with 60Co gamma.Abstract:
Scoring of unstable chromosomes aberrations (dicentrics, rings and fragments) in circulating lymphocytes is the most extensively studied biologic system for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were analyzed by conventional cytogenetic in order to correlate the frequency of chromosome aberrations in lymphocytes with the dose absorbed by the patient, as a result of radiotherapy with 6 0 Co gamma. The samples were collected in three phases of the treatment: before irradiation, 24 hr after receiving 0.08 Gy and 1.8 Gy, respectively. On the basis of the frequencies of unstable aberrations observed, a good agreement was obtained between doses estimated by calibration curve and the doses previously planned to radiotherapy. This report discusses the methodology employed as an important tool for dose assessment as a result of partial-body exposure to ionizing radiation.read more
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Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients.
Valentina d'Alesio,Roberto Pacelli,Marco Durante,Gustavo Canale Cama,Laura Cella,Giancarlo Gialanella,Gianfranco Grossi,Mariagabriella Pugliese,Giorgio Punzo,Ilaria Sardi,P. Scampoli,Raffaele Solla,Marco Salvatore +12 more
TL;DR: The number of lymph nodes within the radiation field is an important factor affecting the yield of radiation-induced chromosomal aberrations in breast cancer patients.
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Unstable chromosomal aberrations and micronuclei analyses in the biomonitoring of workers occupationally exposed to ionising radiation
Thiago de Salazar e Fernandes,Ademir Amaral,Mariana Brayner Cavalcanti,Lidiane Regia Pereira Braga,Raul A. Morais Melo +4 more
TL;DR: Among the individuals, those who do not usually wear a lead apron had higher frequencies of unstable chromosomal aberrations and micronuclei than the ones who carefully observe the radioprotection rules.