Journal ArticleDOI
Unusual Pathogens in Narcotic-Associated Endocarditis
TLDR
Cases of three adults with a history of intravenous drug abuse who developed endocarditis caused by Corynebacterium xerosis, NeISSeria subflava, and Neisseria flavescens are reported, and it is speculated that infection with human immunodeficiency virus may play a role in the pathogenesis of endocardritis caused by these unusual organisms.Abstract:
We report the cases of three adults with a history of intravenous drug abuse who developed endocarditis caused by Corynebacterium xerosis, Neisseria subflava, and Neisseria flavescens, respectively. No cases of endocarditis caused by C. xerosis or N. flavescens and only one case caused by N. subflava have previously been reported in association with narcotic addiction. The prominent clinical features in all patients included poor response to antibiotic therapy, persistent fever, and major embolic events. Stigmata of infection with human immunodeficiency virus, as manifested by oral candidiasis, cervical lymphadenopathy, and serologic evidence, were present in two of the three patients. At our institution, where Staphylococcus aureus remains the most frequent etiologic agent of narcotic-associated endocarditis, the occurrence of these three cases in a 9-month period is striking. We speculate that infection with human immunodeficiency virus may play a role in the pathogenesis of endocarditis caused by these unusual organisms.read more
Citations
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Journal ArticleDOI
Clinical microbiology of coryneform bacteria.
TL;DR: This review provides comprehensive information on the identification of c Coryneform bacteria and outlines recent changes in taxonomy and case reports claiming disease associations of coryneformacteria are critically reviewed.
Journal ArticleDOI
The Medical Complications of Drug Addiction and the Medical Assessment of the Intravenous Drug User: 25 Years Later
TL;DR: This review is intended to provide a historical context to this vast subject and suggest variability in the natural history of intravenous drug use, but as a disease archetype it is a useful pattern for predicting behavior.
Journal ArticleDOI
Emerging bacterial pathogens: the past and beyond
Manon Vouga,Gilbert Greub +1 more
TL;DR: This review focuses on bacterial emerging diseases and explores factors involved in their emergence as well as future challenges, and identified 26 major emerging and reemerging infectious diseases of bacterial origin.
Journal ArticleDOI
Corynebacterium endocarditis species-specific risk factors and outcomes
TL;DR: In addition to species-specific associations with age, gender, prior valvular diseases, and other nosocomial risk factors, the authors found differences in rates of need for valve replacement and death.
References
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Book
Manual of clinical microbiology
TL;DR: A collaborative team of editors and authors from around the world revised the Manual to include the latest applications of genomics and proteomics, producing an authoritative work of two volumes filled with current findings regarding infectious agents, leading-edge diagnostic methods, laboratory practices, and safety guidelines.
Journal ArticleDOI
Infective Endocarditis: An Analysis Based on Strict Case Definitions
TL;DR: Patients in this study had an advanced mean age, high incidence of underlying valvular disease, short mean duration of symptoms, and 15% mortality, the lowest reported for a large series.
Journal ArticleDOI
Bacterial infections in adult patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex.
TL;DR: Sixty-four episodes of bacterial infection were identified over a 44-month period in 16 of 28 patients with the acquired immune deficiency syndrome (AIDS) and 14 of 31 patients with AIDS-related complex, and these infections included meningitis, urinary tract infection, and abscesses involving subcutaneous and deep tissues.
Journal ArticleDOI
Fungal endocarditis: analysis of 24 cases and review of the literature.
TL;DR: Antifungal therapy and/or careful followup should be considered in patients in whom "transient fungemia" is documented by blood culture and serological and untrasonic techniques should be further evaluated as a means of early diagnosis.
Journal ArticleDOI
Bacteremia and fungemia in patients with the acquired immunodeficiency syndrome
Estella Whimbey,Jonathan W. M. Gold,Bruce Polsky,José Dryjanski,Catherine Hawkins,Anne Blevins,Patricia Brannon,Timothy E. Kiehn,Arthur E. Brown,Donald Armstrong +9 more
TL;DR: Because two thirds of the septicemias were caused by organisms other than T-cell opportunists, these pathogens should be anticipated during diagnostic evaluation and when formulating empiric therapy.