Journal ArticleDOI
Bacteremia and fungemia in patients with the acquired immunodeficiency syndrome
Estella Whimbey,Jonathan W. M. Gold,Bruce Polsky,José Dryjanski,Catherine Hawkins,Anne Blevins,Patricia Brannon,Timothy E. Kiehn,Arthur E. Brown,Donald Armstrong +9 more
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Because two thirds of the septicemias were caused by organisms other than T-cell opportunists, these pathogens should be anticipated during diagnostic evaluation and when formulating empiric therapy.Abstract:
Forty-nine episodes of bacteremia and fungemia occurred in 38 of 336 patients with the acquired immunodeficiency syndrome seen at our institution since 1980 There were five types of infecread more
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Journal ArticleDOI
The Clinical Significance of Positive Blood Cultures in the 1990s: A Prospective Comprehensive Evaluation of the Microbiology, Epidemiology, and Outcome of Bacteremia and Fungemia in Adults
Melvin P. Weinstein,M L Towns,S M Quartey,Stanley Mirrett,Larry G. Reimer,Giovanni Parmigiani,L B Reller +6 more
TL;DR: Bloodstream infections in the 1990s are notable for the increased importance of CNS as both contaminants and pathogens, the proportionate increase in fungi and decrease in anaerobes as pathogens,The emergence of Mycobacterium avium complex as an important cause of bacteremia in patients with advanced human immunodeficiency virus infection, and the reduction in mortality associated with infection.
Journal ArticleDOI
Requirement of Interleukin-17A for Systemic Anti-Candida albicans Host Defense in Mice
TL;DR: The data suggest that the mIL- 17A/mIL-17AR system is required for normal fungal host defense in vivo, and IL-17A could have potential as a therapeutic cytokine for systemic C. albicans infections in immunocompromised patients with cancer or advanced acquired immunodeficiency syndrome.
Journal ArticleDOI
Molecular basis of the interaction of Salmonella with the intestinal mucosa.
TL;DR: Animal and in vitro cell culture models for the interaction of enterocolitis-causing salmonellae with the intestinal mucosa are reviewed, along with the bacterial genes that are thought to affect this interaction.
Book ChapterDOI
Risk Assessment of Pseudomonas aeruginosa in Water
TL;DR: Although P. aeruginosa has a reputation for being resistant to disinfection, most studies show that it does not exhibit any marked resistance to the disinfectants used to treat drinking water such as chlorine, chloramines, ozone, or iodine.
Journal ArticleDOI
Bacterial infections in adult patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex.
TL;DR: Sixty-four episodes of bacterial infection were identified over a 44-month period in 16 of 28 patients with the acquired immune deficiency syndrome (AIDS) and 14 of 31 patients with AIDS-related complex, and these infections included meningitis, urinary tract infection, and abscesses involving subcutaneous and deep tissues.
References
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Journal ArticleDOI
Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome.
TL;DR: The scope of immune dysfunction in the acquired immunodeficiency syndrome involves B cells as well as T cells, and it is concluded that the manifestations of B-cell hyperreactivity, such as hypergammaglobulinemia, seen in these patients are due to an in vivo polyclonal activation of B cells.
Journal ArticleDOI
Toxoplasmic encephalitis in patients with acquired immune deficiency syndrome.
TL;DR: The ratio of titers in the agglutination test to titer in the Sabin-Feldman dye test seemed to be more predictive of active toxoplasmic encephalitis in patients with AIDS than either test alone.
Journal ArticleDOI
Cryptococcosis in the acquired immunodeficiency syndrome.
Joseph A. Kovacs,Andrea Kovacs,Michael A. Polis,W. Craig Wright,Vee J. Gill,Carmelita U. Tuazon,Edward P. Gelmann,H. Clifford Lane,Robert Longfield,Gary Overturf,Abe M. Macher,Anthony S. Fauci,Joseph E. Parrillo,John E. Bennett,Henry Masur +14 more
TL;DR: Cryptococcosis in patients with the acquired immunodeficiency syndrome is a debilitating disease that does not respond to conventional therapy; earlier diagnosis or long-term suppressive therapy may improve the prognosis.
Journal ArticleDOI
Pneumocystis carinii Pneumonia in the United States: Epidemiologic, Diagnostic, and Clinical Features
TL;DR: Pneumocystis carinii pneumonia was identified antermortem in 81% of the cases usually by biopsy or needle aspiration of the lung, procedures associated with considerable morbidity and morbidity, and mortality as mentioned in this paper.
Journal ArticleDOI
Bacterial Pneumonia in Patients with the Acquired Immunodeficiency Syndrome
Bruce Polsky,Jonathan W. M. Gold,Estella Whimbey,José Dryjanski,Arthur E. Brown,Gerald Schiffman,Donald Armstrong +6 more
TL;DR: Bacteria associated with B-cell defects should be anticipated when formulating empiric antibiotic therapy, pending a definitive diagnosis, for pulmonary infiltrates in patients with AIDS.