Journal ArticleDOI
Using baseline measurements in the two-period crossover clinical trial.
TLDR
It is found that there are many circumstances in which, in spite of eliminating carryover, the use of baseline measurements provides a less powerful test of treatment effect and a less precise estimate of the treatment difference.About:
This article is published in Controlled Clinical Trials.The article was published on 1986-12-01. It has received 25 citations till now. The article focuses on the topics: Crossover study.read more
Citations
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Journal ArticleDOI
CONSORT 2010 statement: extension to randomised crossover trials.
TL;DR: The CONSORT extension to randomised crossover trials is presented, which aims to facilitate better reporting of crossover trials and revision of the CONSORT 2010 checklist is revised for crossover designs.
Journal ArticleDOI
Randomized placebo-controlled trial of donepezil in patients with progressive supranuclear palsy
TL;DR: The findings suggest that acetylcholinesterase inhibitors such as donepezil have at best selective, modest effects on cognition in patients with PSP, and in light of its deleterious effects on ADL/mobility,donepezil is not recommended for this patient population.
Journal ArticleDOI
A critique of recent research on the two-treatment crossover design.
TL;DR: A critical review is provided of recent articles on two-treatment crossover trials that purport to provide solutions to the problems caused by the existence of differential carryover effects, and recommends the two-period crossover design only when prior experience suggests that its assumptions are likely to be satisfied.
Journal ArticleDOI
The two-period crossover design in medical research.
TL;DR: The crossover design has enjoyed popularity with many clinical researchers, but has been criticized by biostatisticians, with the central problem the inability to derive an unbiased estimate of the treatment effect when differences occur because of the different sequences in which treatments are applied.
Journal ArticleDOI
Ropinirole as a treatment of restless legs syndrome in patients on chronic hemodialysis: an open randomized crossover trial versus levodopa sustained release
Maria Teresa Pellecchia,Carmine Vitale,Massimo Sabatini,Katia Longo,Marianna Amboni,V. Bonavita,Paolo Barone +6 more
TL;DR: It is suggested that ropinirole is more effective than levodopa SR in the treatment of RLS in patients on chronic hemodialysis.
References
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Book
Planning of Experiments
TL;DR: Subjects include the justification and practical difficulties of randomization, various factors occurring in factorial experiments, selecting the size of an experiments, different purposes for which observations may be made and much more.
Journal ArticleDOI
Introduction to sample size determination and power analysis for clinical trials.
TL;DR: The importance of sample size evaluation in clinical trials is reviewed and a general method is presented from which specific equations are derived for sample size determination or the analysis of power for a wide variety of statistical procedures.
Journal ArticleDOI
The two-period change-over design an its use in clinical trials.
TL;DR: This comparison shows that the two-period changeover design is preferable when the residual effects of the treatments are equal and the correlation between the response to the two tieatments is positive, otherwise the design in which there is random assignment to a single treatment is preferable.