Journal ArticleDOI
Variation of resorption rates in vivo of various bones in immature rats.
TLDR
The present data are unique in that they reflect absolute resorption rates in vivo uncomplicated by the extensive re-utilization of calcium inherent in other isotopic or non-isotopic protocols.About:
This article is published in Bone and Mineral.The article was published on 1990-02-01. It has received 15 citations till now. The article focuses on the topics: Resorption & Skull.read more
Citations
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Journal ArticleDOI
High-dose estrogen inhibits bone resorption and stimulates bone formation in the ovariectomized mouse
TL;DR: Results indicate that E2 inhibits bone resorption in femora and vertebrae of OVX mice in a dose‐dependent fashion and has the capacity to stimulate bone formation on both endosteal and cancellous bone surfaces.
Journal ArticleDOI
Cyclosporin-A in Vitro Decreases Bone Resorption, Osteoclast Formation, and the Fusion of Cells of the Monocyte-Macrophage Lineage
TL;DR: It is demonstrated that CyA slightly decreased the proliferation of osteoclast precursors, but markedly decreased their fusion, and similar effects were observed in cultures of rat marrow macrophages.
Journal ArticleDOI
Bone as an effect compartment : models for uptake and release of drugs.
TL;DR: Understanding of the cellular and molecular processes responsible for the heterogeneity of bone tissue will provide better comprehension of the influence of microenvironment on drug bone disposition and the resulting pharmacological response.
Journal ArticleDOI
Cyclosporin A does not affect the absolute rate of cortical bone resorption at the organ level in the growing rat.
TL;DR: The weanling rat, an animal model of rapid bone turnover, was used to evaluate the effects of various doses of cyclosporin A (CsA) on various bones during different time periods, demonstrating that CsA has no effect on the basal rate of bone resorption and decreases rate ofBone formation, as observed globally at the whole bone level.
Journal ArticleDOI
Sex and Strain Differences in Whole Skeletal Development in the Rat
D. L. DeMoss,G. L. Wright +1 more
TL;DR: The results show that skeletal mass developed in the rat is only partially determined by structural support demands and that only a portion of mature skeletal development was related to body mass.
References
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Journal ArticleDOI
Bone Resorption in Tissue Culture. Factors Influencing the Response to Parathyroid Hormone
Journal ArticleDOI
The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. Part IV of IV parts: The state of the bones in uremic hyperaparathyroidism--the mechanisms of skeletal resistance to PTH in renal failure and pseudohypoparathyroidism and the role of PTH in osteoporosis, osteopetrosis, and osteofluorosis.
TL;DR: Kinetic and morphologic studies in patients with parathyroid disease, and a wide variety of studies in experimental animals indicate that one major effect of PTH is to increase the proliferation of osteoprogenitor cells into osteoclasts and so to increase bone turnover.
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The Actions of Parathyroid Hormone on Bone: Relation to Bone Remodeling and Turnover, Calcium Homeostasis, and Metabolic Bone Disease. Part I of IV Parts: Mechanisms of Calcium Transfer Between Blood and Bone and Their Cellular Basis: Morphological and Kinetic Approaches to Bone Turnover
TL;DR: Bone is formed by osteoblasts in successive stages, separated in both time and space, of matrix formation and primary mineralization as discussed by the authors, which is not regulated by the osteoblast.