Showing papers in "Bone and Mineral in 1990"

TL;DR: It is concluded that urinary HP and LP excretion represents the first sensitive and specific marker of bone resorption and should be valuable in the clinical investigation of metabolic bone diseases, especially osteoporosis.

TL;DR: The biochemical and histological findings suggest that long-term glucocorticoid therapy causes a reduction of bone turnover, that the bone loss occurs predominantly within the first 6 months of treatment and that patients with lower bone mass have a lower rate of bone loss.

TL;DR: SEM showed the loss of connectivity in the trabecular network with age--and the remodelling process causing this and confirms and highlights the pathophysiological mechanisms suggested by normal histological studies.

TL;DR: Transilial bone biopsies following in vivo fluorochrome labeling were obtained from 90 women with postmenopausal osteoporosis and 34 healthy post-menopausal women, and there were no major differences in dynamic indices of remodelling.

TL;DR: There is a causal relation between the extent of vertebral destruction measured by the SDI and the extentOf these clinical parameters, and the reduction in quality of life by pain, functional limitations and alterations of mood.

TL;DR: Support is provided for the postulated 'multifunctional' role of the dentin phosphoprotein in the mineralization process by a dose-dependent decrease in the number of mineral clusters formed in the presence of increasing amounts of phosphophoryn, suggesting inhibition of secondary nucleation.

TL;DR: Three of the newer aspects of the vitamin D system which can differ among individuals who do not have overt disease and which should influence the susceptibility to vitamin D toxicity: the concentration of free vitamin D metabolites, the activity of la-hydroxylase and degradative metabolism are discussed.

TL;DR: A special phantom evaluated a special phantom on the three scanners: Lunar DP3, Lunar DPX and Hologic QDR-1000 to investigate the influence of fat on bone in dual-energy absorptiometry measurements, finding that changes in area bone-density were observed if fat was distributed inhomogeneously over the measurement area.

TL;DR: Treatment of patients with vitamin D analogues normalizes calcium absorption and improves calcium balance, which reduces bone resorption and prevents further bone loss; in addition recent studies have shown that therapy with vitaminD analogues leads to a reduction in fracture incidence.

TL;DR: The results indicate that the cells derived from human bone have characteristics of osteoblastic cells.

TL;DR: If the greater osteoid and erosion values in blacks reflect greater bone turnover, then trabecular bone in blacks would be renewed more frequently, be subjected to fewer loading cycles and be less prone to fatigue failure.

TL;DR: The possibility that bone endothelial cells actively participate in the bone remodelling process is proposed and this 'in vitro' model will make possible the analysis of possible influences of the endothelium on bone formation and resorption.

TL;DR: The data suggest that frame size, muscularity and adiposity have independent effects on the skeleton, and that single measurements of each of these anthropometric characteristics are associated with all skeletal sites.

TL;DR: The results suggest that gallium can be adsorbed onto the calcified surface of bone and inhibit osteoclastic bone resorption.

TL;DR: It is suggested that late fracture protection from earlier estrogen therapy is either confined to women with calcium deficiency, or has a non-mass basis (or both).

TL;DR: The prevalence of both osteoporosis and osteomalacia increased with age and, in subjects over the age of 90, osteopOrosis occurred in 71% of patients and osteologicalacia occurred in 29% of Patients, significantly older than the other three groups.

TL;DR: The results show that iron overload and vitamin D deficiency do not seem to play an important role in the pathogenesis of thalassemic bone disease, which is characterized by cortical lesions probably related to marrow hyperactivity.

TL;DR: It is indicated that lower mobility in the elderly leads to higher bone resorption, which may suppress the formation of 1,25-dihydroxyvitamin D.

TL;DR: The influence of age, sex and body size on the bone mineral content of the radius (BMC) measured by single-photon absorptiometry has been studied in 134 British and rural Gambian children aged 0-36 months.

TL;DR: Bone results are preferably expressed as BMD, because (a) intrapopulation variability is lower, (b) intercorrelations among skeletal sites, and even among adjacent vertebrae, are higher for B MD, and (c) the influence of body size on BMD is lower.

TL;DR: Comparison of the biochemically measured TRAP and TrATPase activities showed that bone had the highest specific activity for both enzymes followed by the bone marrow and spleen, however, enzyme activity in the spleen compared to bone was about 4-fold higher for TRAP compared to TratPase.

TL;DR: Unlike in other processes, e.g., direct osteonal and callus-type bone repair, in distraction bone healing gradual distraction of osteotomized bone leads directly to synthesis of mature fibrous organic matrix of bone followed by its rapid mineralization.

TL;DR: The data suggest that there is no abnormality of the osteocalcin carboxylation in Paget's disease, and the disproportionate levels of circulating osteoccin compared to the marked elevation of alkaline phosphatase in that disease could be due to other factors such as an increased binding of the protein to the woven bone matrix.

TL;DR: It is demonstrated that the stimulation of periodontal nerve terminals by means of orthodontic forces may induce the peripheral release of the neurotransmitter SP, suggesting that it may be an initial trigger for a biochemical cascade which comprises the activation of various types of PDL cells.

TL;DR: In developing heterotopic bone in the rat, induced by allogeneic bone matrix, immunohistochemically detected nerves containing substance P, calcitonin gene-related peptide, neuropeptide Y, vasoactive intestinal polypeptides, VIP-immunoreactive fibres and tyrosine hydroxylase, suggesting a neurogenic influence on physiological processes in bone tissue.

TL;DR: It is concluded that LIF stimulates bone resorption by a mechanism involving prostaglandin production, but that a distinct mechanism is responsible for its stimulation of DNA and protein synthesis.

TL;DR: The immunohistochemical profile of osteoclast-reacting monoclonal antibodies, 13C2 and 23C6, known to detect the alpha-chain of the vitronectin receptor, is described, and the nature of the antigens described and the question of osteOClast-specific antibodies are discussed.

TL;DR: OSE may favorably influence osteoporosis by providing a readily available source of calcium by significantly increased from the pre-test value after 12 and 24 months in subjects given OSE by paired t-test, whereas it fell significantly in the controls.

TL;DR: Bone mineral content at onset of disease was lower than normal in only two cases and after 3 years of diabetes no male revealed BMC below the normal range but two females had low BMC values.