Journal ArticleDOI
Vascular Disease in Progressive Systemic Sclerosis (Scleroderma)
Walter L. Norton,John M. Nardo +1 more
TLDR
Clinical, morphological, and functional criteria for progressive systemic sclerosis are studied, and there is no general agreement on the point of pathological impact.Abstract:
Not only is the cause of progressive systemic sclerosis unknown, but there is no general agreement on the point of pathological impact. However, clinical, morphological, and functional obs...read more
Citations
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Journal ArticleDOI
Pathogenesis of systemic sclerosis: a vascular hypothesis.
TL;DR: This hypothesis, linking inflammatory, proliferative, and indurative phases of the vascular lesion, is presented on a background of the general features of systemic sclerosis and is extended to highlight specific points in the management of organ involvement.
Journal ArticleDOI
Myocardial lesions of progressive systemic sclerosis. A cause of cardiac dysfunction.
TL;DR: The findings in patients clearly show that myocardial progressive systemic sclerosis is a distinct entity with relatively frequent occurrence which may lead to arrhythmias, congestive heart failure, angina pectoris with normal coronary arteries and sudden deat.
Journal ArticleDOI
Sequential dermal microvascular and perivascular changes in the development of scleroderma.
Richard J. Prescott,Anthony J. Freemont,Carolyn J.P. Jones,Judith A. Hoyland,Patricia Fielding +4 more
TL;DR: Using conventional light and electron microscopy, immunohistochemistry, and labelled adenosine uptake techniques, changes in the dermal microvasculature have been related to the various clinical stages of skin disease in systemic sclerosis.
Journal ArticleDOI
Cellular infiltrates in scleroderma skin.
TL;DR: Cellular infiltrates, perivascular or diffuse, were noted in 49% of SS and 84% of LS patients and consisted of lymphocytes, plasma cells, and macrophages; no correlation was noted between the presence or severity of skin cellular infiltrates and serum serologic abnormalities.
References
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Journal ArticleDOI
Pathologic observations in systemic sclerosis (scleroderma). A study of fifty-eight autopsy cases and fifty-eight matched controls
TL;DR: The organs found to be frequently and significantly involved by systemic sclerosis were the skin, gastrointestinal tract, lungs, kidneys, skeletal muscle and pericardium, and atrophy was usually a more prominent finding than was fibrosis in organs containing smooth muscle.
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Studies of muscle capillary basement membranes in normal subjects, diabetic, and prediabetic patients
TL;DR: The discovery of thickened capillary basement membranes in prediabetic patients suggests that basement membrane hypertrophy is a relatively early lesion of the diabetic syndrome and provides further support for the conclusion that this vascular defect is independent of carbohydrate derangements of diabetes mellitus.
Journal ArticleDOI
Systemic scleroderma, A clinical study of 727 cases.
TL;DR: A longterm clinical study of scleroderma is believed to be unique in the extremely large number of patients observed, and to add to knowledge of a poorly understood entity.
Journal ArticleDOI
Diffuse collagen disease: acute disseminated lupus erythematosus and diffuse scleroderma.
TL;DR: The thesis of Morgagni that diseases reside in certain organs of the human body has dominated pathologic anatomy and clinical investigation for centuries and has been the cornerstone on which rests the edifice of modern medicine.
Journal ArticleDOI
Scleroderma (based on a study of over 150 cases)
TL;DR: The first description of this condition is credited to Curzio1 of Naples in 1752, and since that time there have been hundreds of cases described.