Patent
Vectors for the expression of an antigenic protein of rabies in eucaryotic cells and application thereof to the preparation of a vaccine
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TLDR
In this article, the vectors for the expression of an antigenic protein of rabies in eucaryotic cells are characterized in that they comprise at least a DNA sequence (1) coding for said antigenic proteins, and the expression elements of said sequence in a eucARYotic cell.Abstract:
The vectors for the expression of an antigenic protein of rabies in eucaryotic cells are characterized in that they comprise at least a DNA sequence (1) coding for said antigenic protein of rabies, and the expression elements of said sequence in a eucaryotic cell. Said vectors may be used to transform eucaryotic cells in order to make them produce an antigenic rabies glycoprotein.read more
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Oral vaccination of mammals
TL;DR: Oral anti-rabies vaccines that comprise at least 100 νg of an isolated rabies glycoprotein G that is produced in eukaryotic cells and methods of immunizing mammals against rabies infection which comprise the step of orally administering to the mammal, such oral antirabies vaccine are disclosed as discussed by the authors.
Patent
Plantes transgeniques exprimant la glycoproteine g de la rage, et glycoproteines ainsi obtenues
Bertrand Merot,Baudino Sylvie,Véronique Gruber,Philippe Bournat,Philippe Lenee,Michel Riviere,Jean-Christophe Francis Audonnet +6 more
TL;DR: In this article, a procedure for the production of glycoproteine G du virus de la rage, ou d'un virus apparente au virus de the rage, caracterise par: i) l'introduction, dans une cellule vegetale, d'une molecule d'acide nucleique comprenant une sequence codante chimerique, comportant d'one part, a peptide signal N-terminal autre que celui naturellement associe a la proteine G virale, and i) the
Patent
TRANSGENIC PLANTS EXPRESSING Rabies GLYCOPROTEIN G, AND GLYCOPROTEINS THUS OBTAINED
Bertrand Merot,Baudino Sylvie,Véronique Gruber,Philippe Bournat,Philippe Lenee,Michel Riviere,Jean-Christophe Francis Audonnet +6 more
TL;DR: In this paper, a method for producing the glycoprotein G of the rabies virus, or a virus related to it, is described, characterised by: i) introducing, into a plant cell, a nucleic acid molecule comprising a chimeric coding sequence, comprising one coding sequence for the said mature viral protein G, or for an analogous protein, and a coded sequence for a N-terminal signal peptide other than the one naturally associated with the virus G, enabling the expression of the protein G in the cell; ii) multiplying, in the form of
Patent
Peptide issu de la proteine g du virus de la rage, ligand du recepteur de basse affinite des neurotrophines(p75ntr) et ses applications
TL;DR: Peptide issu de la proteine G du virus de la rage, ligand du recepteur de basse affinite des neurotrophines (p75NTR) and ses applications comme vecteur pour le transport cible de molecules d'interet dans des cellules exprimant ce recepteur, utile for le traitement des maladies genetiques ou acquises, impliquant un dysfonctionnement of ces cellules, notamment les maladies neurodegeneratives telles que la malad
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Process for preparing sugar-added polypeptides
TL;DR: A process for preparing sugar-added polypeptides, particularly human gamma interferon, which comprises culturing mammal cells transformed by DNA of bovine papilloma virus origin, is incorporated so as to constantly function under the control of Primates virus promoter, then collecting produced sugar-add polypeptic from the culture liquor.
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Expression of polypeptides in yeast
TL;DR: In this paper, the processes of forming transformant strains of yeast and transformed yeast strains are disclosed. DNA expression vectors capable, in a transformant strain of yeast, of expressing a polypeptide under the control of a genetically distinct yeast promoter are described.
Journal ArticleDOI
Rabies Virus Glycoprotein Analogs: Biosynthesis in Escherichia coli
TL;DR: Plasmids are constructed for the direct expression in Escherichia coli of the mature full length rabies glycoprotein gene and also for the expression of a glycop protein gene which has been truncated to exclude the coding region for a hydrophobic, possibly transmembrane, domain of the protein.
Patent
Preparation of polypeptides in vertebrate cell culture
TL;DR: In this paper, the surface antigen is present in 22nm form but contains only mature hepatitis B surface antigen and novel vaccines are provided for immunization against hepatitis b surface antigen.
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Human growth hormone variants
TL;DR: In this article, a novel approach for isolating cDNA for a protein of unknown identity or detectability in native state is presented, which is based on the basis of the present invention and disclosure.
Patent
Rabies immunogenic polypeptides and vaccine using them, DNA sequences, expression vectors, recombinant cells, and cultures therefor, and processes for their production
TL;DR: Polypeptides which correspond to or are analogs of the glycoprotein associated with rabies virus, are synthesized by recombinant DNA technology, thereby poroviding non-infec- tious agents for use as rabies vaccine as mentioned in this paper.