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Journal ArticleDOI

Ventricular fibrillation due to single, localized induction and condenser shocks applied during the vulnerable phase of ventricular systole

Carl J. Wiggers, +1 more
- 31 Jan 1940 - 
- Vol. 128, Iss: 3, pp 500-505
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TLDR
It is shown that in order to produce premature contractions by shocks applied during systole it was necessary to utilize very strong break shocks, and in the zeal to elicit such contractions ventricular fibrillation all too often terminated the experiment.
Abstract
It is generally believed that in order to induce ventricular fibrillation by electric currents they must not only have a minimal intensity but must act for a fair interval of time (ca, several seconds). Indeed, the variation in duration of a current has been used as a criterion of the sensitivity of the heart (1). In 1934 King (2) and in 1936, Ferris, King, Spence and Williams (3) reported that shocks as short as 0.03 second are effective in fibrillating the ventricles provided they are applied during the occurrence of the T wave, which they interpreted as the partial refractory phase. Previous to this, de Boer (4) had shown that a process similar to fibrillation in mammalian hearts can be induced in the frog’s ventricle by induction shocks applied near the end of the systole, but he believed only during a hypodynamic state. Andrus, Carter and Wheeler (5) found that an induction shock similarly introduced into normal auricles of dogs caused auricular fibrillation. During 1923-24 the senior author (6) in studying the response of the dog’s ventricles to strong induction shocks demonstrated that the mammalian ventricle is not refractory to stimuli for a considerable, though apparently variable, interval of systole (last 0.03-0.09 sec. of systole). In order to produce premature contractions by shocks applied during systole it was necessary to utilize very strong break shocks, and in the zeal to elicit such contractions ventricular fibrillation all too often terminated the experiment. A survey of many records has shown that this was due to single shocks and that all were delivered somewhere during the non-refractory phase of ventricular systole. In view of the importance of observations that a very brief shock is capable of inducing fibrillation even when the exciting current traverses only a small area of the ventricle, it seemed important

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Citations
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Book ChapterDOI

The Process of Selecting the Proper Antiarrhythmic Treatment for Patients at High Risk of Sudden Death Following Myocardial Infarction

TL;DR: The purpose of this chapter is to outline the process of selecting the proper antiarrhythmic agent for patients at high risk of sudden death following myocardial infarction.
Journal ArticleDOI

Antifibrillatory effects of class III antiarrhythmic drugs: Evaluation by different methods of ventricular fibrillation threshold (VFT) determination

TL;DR: Proteaseによる局所的出血性壊死心, flecainide, d-sotalol, E-4031の抗細動効果を比較検討した, VFTともに上昇させたが, III群薬はVFT測定
Book ChapterDOI

Basic Mechanisms of Vulnerability to Ventricular Fibrillation

TL;DR: Experimental findings became of importance when in the early decades of this century electrical devices were increasingly installed in households, and more and more people were accidentally electrocuted.
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