Vitamin D status of patients with type 2 diabetes and sputum positive pulmonary tuberculosis
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TLDR
The prevalence of patients with severe vitamin D deficiency is higher in patients with dual affection of TB and diabetes mellitus as compared with either disorder alone implying that patients with type 2 diabetes with the most severe vitaminD deficiency are the one of the most predisposed to pulmonary TB.Abstract:
Introduction: Vitamin D deficiency is expected to be higher in patients with diabetes and pulmonary tuberculosis (TB). Studies estimating prevalence in the subset of patients with both diabetes and pulmonary TB are scarce. Materials and Methods: A total of 155 subjects were recruited; 46 patients with type 2 diabetes, 39 non-diabetic healthy controls, 30 patients of pulmonary TB and 40 patients with both pulmonary TB and type 2 diabetes. Vitamin D level (25 OH vitamin D) levels were done for all the 4 groups. Results: Mean vitamin D levels were not different between groups with TB, diabetes mellitus or combination of both, but the prevalence of severe vitamin D deficiency was higher in the group with both diabetes and TB (45%) as compared with the group with only TB (26.66%) and diabetes (17.39%) and healthy controls (7.69%). Conclusion: The prevalence of patients with severe vitamin D deficiency is higher in patients with dual affection of TB and diabetes mellitus as compared with either disorder alone implying that patients with type 2 diabetes with the most severe vitamin D deficiency are the one of the most predisposed to pulmonary TB.read more
Citations
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Journal ArticleDOI
Vitamin D deficiency and the risk of tuberculosis: a meta-analysis.
TL;DR: The authors' analyses revealed an association between vitamin D and TB that VDD is more likely a risk factor for TB than its consequence, and the result that anti-TB treatment did not affect vitamin D level in TB patients receiving the treatment was strengthened.
Journal ArticleDOI
Type 2 Diabetes Mellitus as a Risk Factor for Tuberculosis
TL;DR: Empirical analyses have elucidated an association between DM and the development of TB, and suggest that vaccination against tuberculosis is a viable treatment option for DM-related TB.
Journal ArticleDOI
Assessment of Polymorphism of the VDR Gene and Serum Vitamin D Values in Gestational Diabetes Mellitus.
TL;DR: There was no association between the FokI polymorphism and the development of GDM, nor was there any change in serum vitamin D levels in patients with GDM.
Journal ArticleDOI
Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study.
Noémie Boillat-Blanco,Pascal Bovet,Kaushik Ramaiya,Maliwasa Mganga,Lilian T. Minja,Lanja Saleh,Medea Imboden,Christian Schindler,Christian Schindler,Sebastien Gagneux,Sebastien Gagneux,Claudia Daubenberger,Claudia Daubenberger,Klaus Reither,Klaus Reither,Klaus Reither,Nicole Probst-Hensch,Nicole Probst-Hensch +17 more
TL;DR: Low 25(OH)D may increase TB risk in patients with underlying DM and trials should examine if this association is causal and whether adjunct vitamin D therapy is beneficial in this population.
Journal ArticleDOI
Vitamin D status in tuberculosis patients with diabetes, prediabetes and normal blood glucose in China: a cross-sectional study.
Xin Zhao,Yanli Yuan,Yan Lin,Tiejuan Zhang,Jianjun Ma,Wanli Kang,Yunlong Bai,Yunlong Wang,Hongshan Shao,Riitta A Dlodlo,Anthony D. Harries +10 more
TL;DR: Vitamin D levels are lower in patients with TB with pre-DM and DM and are also affected by certain baseline characteristics that include being registered in the cold season and having DM.
References
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Diabetes Mellitus Increases the Risk of Active Tuberculosis: A Systematic Review of 13 Observational Studies
Christie Y. Jeon,Megan Murray +1 more
TL;DR: DM was associated with an increased risk of TB regardless of study design and population and efforts to diagnose, detect, and treat DM may have a beneficial impact on TB control.
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High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India.
TL;DR: A high prevalence of physiologically significant hypovitaminosis D among pregnant women and their newborns is observed, the magnitude of which warrants public health intervention.
Journal ArticleDOI
A single dose of vitamin D enhances immunity to mycobacteria.
Adrian R. Martineau,Robert J. Wilkinson,Katalin A. Wilkinson,Sandra M. Newton,Beate Kampmann,Bridget M. Hall,Geoffrey E. Packe,Robert N. Davidson,Sandra Eldridge,Zoë J. Maunsell,Sandra J. Rainbow,Jacqueline L. Berry,Chris Griffiths +12 more
TL;DR: Vitamin D supplementation significantly enhanced the ability of participants' whole blood to restrict BCG-lux luminescence in vitro without affecting antigen-stimulated IFN-gamma responses, and should be performed to determine whether vitamin D supplementation prevents reactivation of latent TB infection.
Journal ArticleDOI
High prevalence of low dietary calcium, high phytate consumption, and vitamin D deficiency in healthy south Indians
Harinarayan Cv,Tirupati Ramalakshmi,Upadrasta V. Prasad,Desineni Sudhakar,Pemmaraju V L N Srinivasarao,K V S Sarma,Ethamakula G Tiruvenkata Kumar +6 more
TL;DR: Low dietary calcium intake and 25(OH)D concentrations were associated with deleterious effects on bone mineral homeostasis and Prospective longitudinal studies are required to assess the effect on bone Mineral density, a surrogate marker for fracture risk and fracture rates.
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Vitamin D status and its relationship with bone mineral density in healthy Asian Indians
TL;DR: The findings show that vitamin D deficiency is common in urban north Indian hospital staff, and the possible reasons include inadequate sunlight exposure and skin pigmentation in Indians.