S
Sebastien Gagneux
Researcher at University of Basel
Publications - 271
Citations - 21422
Sebastien Gagneux is an academic researcher from University of Basel. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 70, co-authored 254 publications receiving 18285 citations. Previous affiliations of Sebastien Gagneux include Ministry of Health (Ghana) & Centre national de la recherche scientifique.
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Journal ArticleDOI
Variable host-pathogen compatibility in Mycobacterium tuberculosis.
Sebastien Gagneux,Kathryn DeRiemer,Tran Van,Midori Kato-Maeda,Bouke C. de Jong,Sujatha Narayanan,Mark P. Nicol,Stefan Niemann,Kristin Kremer,M. Cristina Gutierrez,Markus Hilty,Philip C. Hopewell,Peter M. Small +12 more
TL;DR: It is demonstrated that the global population structure of M. tuberculosis is defined by six phylogeographical lineages, each associated with specific, sympatric human populations, and in an urban cosmopolitan environment, mycobacterial lineages were much more likely to spread in sympatrics than in allopatric patient populations.
Journal ArticleDOI
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
Iñaki Comas,Mireia Coscolla,Mireia Coscolla,Tao Luo,Sonia Borrell,Sonia Borrell,Kathryn E. Holt,Midori Kato-Maeda,Julian Parkhill,Bijaya Malla,Bijaya Malla,Stefan Berg,Guy E. Thwaites,Dorothy Yeboah-Manu,Graham H. Bothamley,Jian Mei,Lan-Hai Wei,Stephen D. Bentley,Simon R. Harris,Stefan Niemann,Roland Diel,Abraham Aseffa,Qian Gao,Douglas B. Young,Douglas B. Young,Sebastien Gagneux,Sebastien Gagneux +26 more
TL;DR: Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period, consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities.
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Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development
TL;DR: A strain selection framework is proposed, based on robust phylogenetic markers, which will allow for systematic and comprehensive evaluation of new tools for tuberculosis control and suggest strain-specific differences in virulence and immunogenicity.
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Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved
Iñaki Comas,Jaidip Chakravartti,Peter M. Small,James E. Galagan,Stefan Niemann,Kristin Kremer,Joel D. Ernst,Sebastien Gagneux,Sebastien Gagneux,Sebastien Gagneux +9 more
TL;DR: A genome-wide phylogeny based on genomes of 21 strains representative of the global diversity and six major lineages of the M. tuberculosis complex showed, as expected, that essential genes in MTBC were more evolutionarily conserved than nonessential genes.
Journal ArticleDOI
The competitive cost of antibiotic resistance in Mycobacterium tuberculosis.
Sebastien Gagneux,Clara Davis Long,Peter M. Small,Peter M. Small,Tran Van,Gary K. Schoolnik,Brendan J. M. Bohannan +6 more
TL;DR: It is demonstrated that prolonged patient treatment can result in multidrug-resistant strains with no fitness defect and that strains with low- or no-cost resistance mutations are also the most frequent among clinical isolates.