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Medea Imboden
Researcher at University of Basel
Publications - 156
Citations - 11739
Medea Imboden is an academic researcher from University of Basel. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 47, co-authored 143 publications receiving 9654 citations. Previous affiliations of Medea Imboden include Erasmus University Rotterdam & University of Zurich.
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Journal ArticleDOI
New loci associated with kidney function and chronic kidney disease
Anna Köttgen,Anna Köttgen,Cristian Pattaro,Carsten A. Böger,Christian Fuchsberger,Matthias Olden,Nicole L. Glazer,Afshin Parsa,Xiaoyi Gao,Qiong Yang,Albert V. Smith,Jeffrey R. O'Connel,Man Li,Helena Schmidt,Toshiko Tanaka,Toshiko Tanaka,Aaron Isaacs,Shamika Ketkar,Shih-Jen Hwang,Andrew D. Johnson,Abbas Dehghan,Alexander Teumer,Guillaume Paré,Elizabeth J. Atkinson,Tanja Zeller,Kurt Lohman,Marilyn C. Cornelis,Nicole Probst-Hensch,Nicole Probst-Hensch,Florian Kronenberg,Anke Tönjes,Caroline Hayward,Thor Aspelund,Gudny Eiriksdottir,Lenore J. Launer,Tamara B. Harris,Evadnie Rampersaud,Braxton D. Mitchel,Dan E. Arking,Eric Boerwinkle,Maksim Struchalin,Margherita Cavalieri,Andrew B. Singleton,Francesco Giallauria,Jeffrey Metter,Ian H. de Boer,Talin Haritunians,Thomas Lumley,David S. Siscovick,Bruce M. Psaty,M. CarolaZillikens,Ben A. Oostra,Mary F. Feitosa,Michael A. Province,Mariza de Andrade,Stephen T. Turner,Arne Schillert,Andreas Ziegler,Philipp S. Wild,Renate B. Schnabel,Sandra Wilde,Thomas Münzel,Tennille S. Leak,Thomas Illig,Norman Klopp,Christa Meisinger,H.-Erich Wichmann,Wolfgang Koenig,Lina Zgaga,Tatijana Zemunik,Ivana Kolcic,Cosetta Minelli,Frank B. Hu,Åsa Johansson,Wilmar Igl,Ghazal Zaboli,Sarah H. Wild,Alan F. Wright,Harry Campbell,David Ellinghaus,Stefan Schreiber,Yurii S. Aulchenko,Janine F. Felix,Fernando Rivadeneira,André G. Uitterlinden,Albert Hofman,Medea Imboden,Medea Imboden,Dorothea Nitsch,Anita Brandstätter,Barbara Kollerits,Lyudmyla Kedenko,Reedik Mägi,Michael Stumvoll,Peter Kovacs,Mladen Boban,Susan Campbell,Karlhans Endlich,Henry Völzke,Heyo K. Kroemer,Matthias Nauck,Uwe Völker,Ozren Polasek,Veronique Vitart,Sunita Badola,Alex Parker,Paul M. Ridker,Sharon L.R. Kardia,Stefan Blankenberg,Yongmei Liu,Gary C. Curhan,Andre Franke,Thierry Rochat,Bernhard Paulweber,Inga Prokopenko,Wei Wang,Wei Wang,Vilmundur Gudnason,Alan R. Shuldine,Josef Coresh,Reinhold E. Schmidt,Luigi Ferrucci,Michael G. Shlipak,Cornelia M. van Duijn,Ingrid B. Borecki,Bernhard K. Krämer,Igor Rudan,Ulf Gyllensten,James F. Wilson,Jacqueline C. M. Witteman,Peter P. Pramstaller,Rainer Rettig,Nicholas D. Hastie,Daniel I. Chasman,Wen Hong L. Kao,Iris M. Heid,Caroline S. Fox,Caroline S. Fox +137 more
TL;DR: The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry to identify new susceptibility loci for reduced renal function as estimated by serum creatinine, serum cystatin c and CKD.
Journal ArticleDOI
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Anna Köttgen,Anna Köttgen,Eva Albrecht,Alexander Teumer,Veronique Vitart,Jan Krumsiek,Claudia Hundertmark,Giorgio Pistis,Daniela Ruggiero,Conall M. O'Seaghdha,Conall M. O'Seaghdha,Toomas Haller,Qiong Yang,Qiong Yang,Toshiko Tanaka,Andrew D. Johnson,Zoltán Kutalik,Zoltán Kutalik,Albert V. Smith,Julia Shi,Maksim Struchalin,Rita P. S. Middelberg,Morris J. Brown,Angelo L. Gaffo,Nicola Pirastu,Guo Li,Caroline Hayward,Tatijana Zemunik,Jennifer E. Huffman,Loic Yengo,Jing Hua Zhao,Ayse Demirkan,Mary F. Feitosa,Xuan Liu,Giovanni Malerba,Lorna M. Lopez,Pim van der Harst,Xinzhong Li,Marcus E. Kleber,Andrew A. Hicks,Ilja M. Nolte,Åsa Johansson,Federico Murgia,Sarah H. Wild,Stephan J. L. Bakker,John F. Peden,Abbas Dehghan,Maristella Steri,Albert Tenesa,Vasiliki Lagou,Perttu Salo,Massimo Mangino,Lynda M. Rose,Terho Lehtimäki,Owen M. Woodward,Yukinori Okada,Adrienne Tin,Christian Müller,Christopher Oldmeadow,Margus Putku,Darina Czamara,Peter Kraft,Laura Frogheri,Gian Andri Thun,Gian Andri Thun,Anne Grotevendt,Gauti Kjartan Gislason,Tamara B. Harris,Lenore J. Launer,Patrick F. McArdle,Alan R. Shuldiner,Eric Boerwinkle,Josef Coresh,Helena Schmidt,Michael Schallert,Nicholas G. Martin,Grant W. Montgomery,Michiaki Kubo,Yusuke Nakamura,Toshihiro Tanaka,Patricia B. Munroe,Nilesh J. Samani,Nilesh J. Samani,David R. Jacobs,Kiang Liu,Pio D'Adamo,Sheila Ulivi,Jerome I. Rotter,Bruce M. Psaty,Bruce M. Psaty,Peter Vollenweider,Gérard Waeber,Susan Campbell,Olivier Devuyst,Pau Navarro,Ivana Kolcic,Nicholas D. Hastie,Beverley Balkau,Philippe Froguel,Tõnu Esko,Andres Salumets,Kay-Tee Khaw,Claudia Langenberg,Nicholas J. Wareham,Aaron Isaacs,Aldi Kraja,Qunyuan Zhang,Qunyuan Zhang,Philipp S. Wild,Rodney J. Scott,Elizabeth G. Holliday,Elin Org,Margus Viigimaa,Stefania Bandinelli,Jeffrey Metter,Antonio Lupo,Elisabetta Trabetti,Rossella Sorice,Angela Döring,Eva Lattka,Konstantin Strauch,Fabian J. Theis,Melanie Waldenberger,H.-Erich Wichmann,Gail Davies,Alan J. Gow,Marcel Bruinenberg,Ronald P. Stolk,Jaspal S. Kooner,Jaspal S. Kooner,Weihua Zhang,Weihua Zhang,Bernhard R. Winkelmann,Bernhard O. Boehm,Susanne Lucae,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Johannes H. Smit,Gary C. Curhan,Poorva Mudgal,Poorva Mudgal,Robert M. Plenge,Robert M. Plenge,Laura Portas,Ivana Persico,Mirna Kirin,James F. Wilson,Irene Mateo Leach,Wiek H. van Gilst,Anuj Goel,Halit Ongen,Albert Hofman,Fernando Rivadeneira,André G. Uitterlinden,Medea Imboden,Medea Imboden,Arnold von Eckardstein,Francesco Cucca,Ramaiah Nagaraja,Maria Grazia Piras,Matthias Nauck,Claudia Schurmann,Kathrin Budde,Florian Ernst,Susan M. Farrington,Evropi Theodoratou,Inga Prokopenko,Michael Stumvoll,A. Jula,Markus Perola,Markus Perola,Markus Perola,Veikko Salomaa,So-Youn Shin,Tim D. Spector,Cinzia Sala,Paul M. Ridker,Mika Kähönen,Jorma Viikari,Christian Hengstenberg,Christopher P. Nelson,Christopher P. Nelson,James F. Meschia,Mike A. Nalls,Pankaj Sharma,Andrew B. Singleton,Naoyuki Kamatani,Tanja Zeller,Michel Burnier,John Attia,Maris Laan,Norman Klopp,Hans L. Hillege,Stefan Kloiber,Hyon K. Choi,Hyon K. Choi,Mario Pirastu,Silvia Tore,Nicole Probst-Hensch,Nicole Probst-Hensch,Henry Völzke,Vilmundur Gudnason,Afshin Parsa,Reinhold Schmidt,John Whitfield,Myriam Fornage,Paolo Gasparini,David S. Siscovick,Ozren Polasek,Harry Campbell,Igor Rudan,Igor Rudan,Nabila Bouatia-Naji,Andres Metspalu,Ruth J. F. Loos,Cornelia M. van Duijn,Ingrid B. Borecki,Luigi Ferrucci,Giovanni Gambaro,Ian J. Deary,Bruce H. R. Wolffenbuttel,John C. Chambers,John C. Chambers,Winfried März,Winfried März,Peter P. Pramstaller,Harold Snieder,Ulf Gyllensten,Alan F. Wright,Gerjan Navis,Hugh Watkins,Jacqueline C.M. Witteman,Serena Sanna,Sabine Schipf,Malcolm G. Dunlop,Anke Tönjes,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Nicole Soranzo,Daniela Toniolo,Daniel I. Chasman,Olli T. Raitakari,W. H. Linda Kao,Marina Ciullo,Caroline S. Fox,Caroline S. Fox,Mark J. Caulfield,Murielle Bochud,Christian Gieger +250 more
TL;DR: New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.
Journal ArticleDOI
Genome-wide association study identifies five loci associated with lung function.
Emmanouela Repapi,Ian Sayers,Louise V. Wain,Paul Burton,Toby Johnson,Ma'en Obeidat,Jing Hua Zhao,Adaikalavan Ramasamy,Guangju Zhai,Veronique Vitart,Jennifer E. Huffman,Wilmar Igl,E Albrecht,Panagiotis Deloukas,John Henderson,Raquel Granell,Wendy L. McArdle,Alicja R. Rudnicka,Inês Barroso,Loos Rjf.,Nicholas J. Wareham,Linda Mustelin,Taina Rantanen,Ida Surakka,Ida Surakka,Medea Imboden,H E Wichmann,Ivica Grković,Stipan Janković,Lina Zgaga,Hartikainen A-L.,Hartikainen A-L.,Hartikainen A-L.,Leena Peltonen,Leena Peltonen,Leena Peltonen,Ulf Gyllensten,Åsa Johansson,Ghazal Zaboli,Harry Campbell,Sarah H. Wild,James F. Wilson,Sven Gläser,Georg Homuth,Henry Völzke,Massimo Mangino,Nicole Soranzo,Nicole Soranzo,Tim D. Spector,Ozren Polasek,Igor Rudan,Igor Rudan,Alan F. Wright,Markku Heliövaara,Samuli Ripatti,Samuli Ripatti,Anneli Pouta,Åsa Torinsson Naluai,Olin A-C.,Kjell Torén,Mark E. Cooper,Alan James,Lyle J. Palmer,Lyle J. Palmer,Aroon D. Hingorani,S.G. Wannamethee,Peter H. Whincup,George Davey Smith,Shah Ebrahim,Tricia M. McKeever,Ian D. Pavord,Andrew K. MacLeod,Andrew D. Morris,David J. Porteous,Cyrus Cooper,Cyrus Cooper,Elaine M. Dennison,Seif O. Shaheen,Stefan Karrasch,E Schnabel,Holger Schulz,H Grallert,Nabila Bouatia-Naji,Jérôme Delplanque,Philippe Froguel,Philippe Froguel,John D Blakey,John Britton,Richard W Morris,John W. Holloway,Debbie A Lawlor,Jennie Hui,Jennie Hui,Fredrik Nyberg,Fredrik Nyberg,Jarvelin M-R.,Catherine Jackson,Mika Kähönen,Jaakko Kaprio,Jaakko Kaprio,Nicole Probst-Hensch,Nicole Probst-Hensch,Beate Koch,Caroline Hayward,David M. Evans,Paul Elliott,Paul Elliott,David P. Strachan,Ian P. Hall,Martin D. Tobin +109 more
TL;DR: Genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium offers mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Anna Koettgen,Eva Albrecht,Alexander Teumer,Veronique Vitart,Jan Krumsiek,Claudia Hundertmark,Giorgio Pistis,Daniela Ruggiero,Conall M. O'Seaghdha,Toomas Haller,Qiong Yang,Toshiko Tanaka,Andrew D. Johnson,Zoltán Kutalik,Albert V. Smith,Julia Shi,Maksim Struchalin,Rita P. S. Middelberg,Morris J. Brown,Angelo L. Gaffo,Nicola Pirastu,Guo Li,Caroline Hayward,Tatijana Zemunik,Jennifer E. Huffman,Loic Yengo,Jing Hua Zhao,Ayse Demirkan,Mary F. Feitosa,Xuan Liu,Giovanni Malerba,Lorna M. Lopez,Pim van der Harst,Xinzhong Li,Marcus E. Kleber,Andrew A. Hicks,Ilja M. Nolte,Åsa Johansson,Federico Murgia,Sarah H. Wild,Stephan J. L. Bakker,John F. Peden,Abbas Dehghan,Maristella Steri,Albert Tenesa,Vasiliki Lagou,Perttu Salo,Massimo Mangino,Lynda M. Rose,Terho Lehtimäki,Owen M. Woodward,Yukinori Okada,Adrienne Tin,Christian Mueller,Christopher Oldmeadow,Margus Putku,Darina Czamara,Peter Kraft,Laura Frogheri,Gian Andri Thun,Anne Grotevendt,Gauti Kjartan Gislason,Tamara B. Harris,Lenore J. Launer,Patrick F. McArdle,Alan R. Shuldiner,Eric Boerwinkle,Josef Coresh,Helena Schmidt,Michael Schallert,Nicholas G. Martin,Grant W. Montgomery,Michiaki Kubo,Yusuke Nakamura,Toshihiro Tanaka,Patricia B. Munroe,Nilesh J. Samani,David R. Jacobs,Kiang Liu,Pio D'Adamo,Sheila Ulivi,Jerome I. Rotter,Bruce M. Psaty,Peter Vollenweider,Gérard Waeber,Susan Campbell,Olivier Devuyst,Pau Navarro,Ivana Kolcic,Nicholas D. Hastie,Beverley Balkau,Philippe Froguel,Tõnu Esko,Andres Salumets,Kay-Tee Khaw,Claudia Langenberg,Nicholas J. Wareham,Aaron Isaacs,Aldi T. Kraja,Qunyuan Zhang,Philipp S. Wild,Rodney J. Scott,Elizabeth G. Holliday,Elin Org,Margus Viigimaa,Stefania Bandinelli,Jeffrey Metter,Antonio Lupo,Elisabetta Trabetti,Rossella Sorice,Angela Doering,Eva Lattka,Konstantin Strauch,Fabian J. Theis,Melanie Waldenberger,H-Erich Wichmann,Gail Davies,Alan J. Gow,Marcel Bruinenberg,Ronald P. Stolk,Jaspal S. Kooner,Weihua Zhang,Bernhard R. Winkelmann,Bernhard O. Boehm,Susanne Lucae,Brenda W.J.H. Penninx,Johannes H. Smit,Gary C. Curhan,Poorva Mudgal,Robert M. Plenge,Laura Portas,Ivana Persico,Mirna Kirin,James F. Wilson,Irene Mateo Leach,Wiek H. van Gilst,Anuj Goel,Halit Ongen,Albert Hofman,Fernando Rivadeneira,André G. Uitterlinden,Medea Imboden,Arnold von Eckardstein,Francesco Cucca,Ramaiah Nagaraja,Maria Grazia Piras,Matthias Nauck,Claudia Schurmann,Kathrin Budde,Florian Ernst,Susan M. Farrington,Evropi Theodoratou,Inga Prokopenko,Michael Stumvoll,Antti Jula,Markus Perola,Veikko Salomaa,So-Youn Shin,Tim D. Spector,Cinzia Sala,Paul M. Ridker,Mika Kaehoenen,Jorma Viikari,Christian Hengstenberg,Christopher P. Nelson,James F. Meschia,Mike A. Nalls,Pankaj Sharma,Andrew B. Singleton,Naoyuki Kamatani,Tanja Zeller,Michel Burnier,John Attia,Maris Laan,Norman Klopp,Hans L. Hillege,Stefan Kloiber,Hyon K. Choi,Mario Pirastu,Silvia Tore,Nicole Probst-Hensch,Henry Voelzke,Vilmundur Gudnason,Afshin Parsa,Reinhold E. Schmidt,John Whitfield,Myriam Fornage,Paolo Gasparini,David S. Siscovick,Ozren Polasek,Harry Campbell,Igor Rudan,Nabila Bouatia-Naji,Andres Metspalu,Ruth J. F. Loos,Cornelia M. van Duijn,Ingrid B. Borecki,Luigi Ferrucci,Giovanni Gambaro,Ian J. Deary,Bruce H. R. Wolffenbuttel,John C. Chambers,Winfried Maerz,Peter P. Pramstaller,Harold Snieder,Ulf Gyllensten,Alan F. Wright,Gerjan Navis,Hugh Watkins,Jacqueline C.M. Witteman,Serena Sanna,Sabine Schipf,Malcolm G. Dunlop,Anke Toenjes,Samuli Ripatti,Nicole Soranzo,Daniela Toniolo,Daniel I. Chasman,Olli T. Raitakari,W. H. Linda Kao,Marina Ciullo,Caroline S. Fox,Mark J. Caulfield,Murielle Bochud,Christian Gieger +224 more
TL;DR: In this article, the authors identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4).
Journal ArticleDOI
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Lavinia Paternoster,Marie Standl,Johannes Waage,H. Baurecht,Melanie Hotze,David P. Strachan,John A. Curtin,Klaus Bønnelykke,Chao Tian,Atsushi Takahashi,Jorge Esparza-Gordillo,Alexessander Couto Alves,Jacob P. Thyssen,Herman T. den Dekker,Manuel A. R. Ferreira,Elisabeth Altmaier,Patrick M. A. Sleiman,Patrick M. A. Sleiman,Feng Li Xiao,Juan R. González,Juan R. González,Ingo Marenholz,Birgit Kalb,Maria Pino-Yanes,Maria Pino-Yanes,Cheng-Jian Xu,Lisbeth Carstensen,Maria M. Groen-Blokhuis,Cristina Venturini,Craig E. Pennell,Sheila J. Barton,Albert M. Levin,Ivan Curjuric,Ivan Curjuric,Mariona Bustamante,Eskil Kreiner-Møller,Gabrielle A. Lockett,Jonas Bacelis,Supinda Bunyavanich,Rachel A. Myers,Anja Matanovic,Ashok Kumar,Joyce Y. Tung,Tomomitsu Hirota,Michiaki Kubo,Wendy L. McArdle,A. John Henderson,John P. Kemp,John P. Kemp,Jie Zheng,George Davey Smith,Franz Rueschendorf,Anja Bauerfeind,Min Ae Lee-Kirsch,Andreas Arnold,Georg Homuth,Carsten Oliver Schmidt,Elisabeth Mangold,Sven Cichon,Thomas Keil,Elke Rodriguez,Annette Peters,Andre Franke,Wolfgang Lieb,Natalija Novak,Regina Foelster-Holst,Momoko Horikoshi,Juha Pekkanen,Sylvain Sebert,Lise Lotte N. Husemoen,Niels Grarup,Johan C. de Jongste,Fernando Rivadeneira,Albert Hofman,Vincent W. V. Jaddoe,Suzanne G.M.A. Pasmans,Niels J. Elbert,André G. Uitterlinden,Guy B. Marks,Philip J. Thompson,Melanie C. Matheson,Colin F. Robertson,Janina S. Ried,Jin Li,Xian Bo Zuo,X. Zheng,Xianyong Yin,Liangdan Sun,Maeve A. McAleer,Grainne M. O'Regan,Caoimhe M. R. Fahy,Linda E. Campbell,Milan Macek,Michael Kurek,Donglei Hu,Celeste Eng,Dirkje S. Postma,Bjarke Feenstra,Frank Geller,Jouke-Jan Hottenga,Christel M. Middeldorp,Pirro G. Hysi,Veronique Bataille,Tim D. Spector,Carla M. T. Tiesler,Elisabeth Thiering,Badri Pahukasahasram,James J. Yang,Medea Imboden,Scott Huntsman,Natalia Vilor-Tejedor,Caroline L Relton,Ronny Myhre,Wenche Nystad,Adnan Custovic,Scott T. Weiss,Deborah A. Meyers,Cilla Soederhaell,Erik Melén,Carole Ober,Benjamin A. Raby,Angela Simpson,Bo Jacobsson,John W. Holloway,Hans Bisgaard,Jordi Sunyer,Nicole Probst-Hensch,L. Keoki Williams,Keith M. Godfrey,Carol A. Wang,Dorret I. Boomsma,Mads Melbye,Gerard H. Koppelman,Deborah Jarvis,W.H. Irwin McLean,Alan D. Irvine,Xuejun Zhang,Hakon Hakonarson,Christian Gieger,Esteban G. Burchard,Nicholas G. Martin,Liesbeth Duijts,Allan Linneberg,Marjo-Riitta Järvelin,Markus M. Noethen,Susanne Lau,Norbert Huebner,Young-Ae Lee,Mayumi Tamari,David A. Hinds,Daniel Glass,Sara J. Brown,Joachim Heinrich,David M. Evans,Stephan Weidinger +154 more
TL;DR: This paper performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies.