Wild-Type and Recombinant AAV Integration in Human Cardiomyocytes: Focus on Mitochondrial Genome
Jessika Ceiler,Saira Afzal,Barbara Leuchs,Raffaele Fronza,Christina Lulay,Hildegard Büning,Manfred Schmidt,Irene Gil-Farina +7 more
Reads0
Chats0
About:
This article is published in Molecular Therapy.The article was published on 2017-05-01 and is currently open access. It has received 6 citations till now. The article focuses on the topics: Wild type.read more
Citations
More filters
Journal ArticleDOI
Gene therapy for neurological disorders: progress and prospects
Benjamin E. Deverman,Benjamin E. Deverman,Bernard Ravina,Krystof S. Bankiewicz,Steven M. Paul,Dinah W. Y. Sah +5 more
TL;DR: Key considerations and challenges in the future design and development of therapeutic AAV vectors are discussed, highlighting the most promising targets and recent clinical advances.
Journal ArticleDOI
Severe Heterotopic Ossification in the Skeletal Muscle and Endothelial Cells Recruitment to Chondrogenesis Are Enhanced by Monocyte/Macrophage Depletion.
Mario Tirone,Anna Giovenzana,Arianna Vallone,Paola Zordan,Martina Sormani,Pier Andrea Nicolosi,Raffaela Meneveri,Carmen R. Gigliotti,Antonello E. Spinelli,Renata Bocciardi,Roberto Ravazzolo,Roberto Ravazzolo,Ingrid Cifola,Silvia Brunelli +13 more
TL;DR: Altered macrophage infiltration upon tissue damage results in inadequate healing due to inappropriate remodeling and stem cell recruitment and differentiation, and alterations of the macrophages-endothelial axis may represent a novel target for molecular intervention in heterotopic ossification.
Journal ArticleDOI
Integration Site Analysis in Gene Therapy Patients: Expectations and Reality.
TL;DR: This review is aimed at providing a brief overview of what the current state and the future is of these studies with a particular focus on retroviral vectors.
Book ChapterDOI
Monoclonal Antibody-Conjugated Dendritic Nanostructures for siRNA Delivery.
TL;DR: A targeted carrier system is described that can deliver siRNA to cancer cells overexpressing the human epidermal growth factor 2 (HER2) receptor using trastuzumab-conjugated poly(amido)amine dendrimers.
Journal ArticleDOI
Strategic advancements and multimodal applications of biofilm therapy
Varun S Wakade,Pravin Shende +1 more
TL;DR: The authors focus on the novel applications of biofilms such as adhesives, tissue engineering, targeted delivery system, probiotics, nutrients delivery, etc, for better therapeutic action.