Xanthones and Xanthone O‐β‐D‐Glucosides from the Roots of Polygala azizsancarii Dönmez
Ihsan Calis,Ayşe Ezgi Ünlü,Zübeyde Uğurlu Aydın,Ali A. Dönmez,Hasan Soliman Yusufoğlu,Simon Jurt,Anthony Linden +6 more
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In this article , nine xanthone derivatives (1−9) were isolated from the roots of Polygala azizsancarii, which is a narrow endemic species for the flora of Türkiye.Abstract:
Nine xanthone derivatives (1–9) were isolated from the roots of Polygala azizsancarii, which is a narrow endemic species for the flora of Türkiye. Based on all of the evidence, the structures of 1–9 were established as two previously undescribed xanthone O‐glucosides, 3‐O‐β‐D‐glucopyranosyloxy‐1,6‐dihydroxy‐2,5,7‐trimethoxyxanthone (1), 3‐O‐β‐D‐glucopyranosyloxy‐1,6‐dihydroxy‐2,7‐dimethoxyxanthone (2), and seven previously described xanthones, 1,3,6‐trihydroxy‐2,5,7‐trimethoxyxanthone (3), 1,3,6‐trihydroxy‐2,7‐dimethoxyxanthone (4), 1,2,3,4,7‐pentamethoxyxanthone (5), 1,3‐dihydroxy‐2,5,6,7‐tetramethoxyxanthone (6), 1,3‐dihydroxy‐4,7‐dimethoxyxanthone (7), 1,7‐dihydroxy‐3‐methoxyxanthone (8), and 1,7‐dihydroxy‐2,3‐methylenedioxyxanthone (9). The structures of the compounds were determined by spectroscopic methods, including 1D‐NMR (1H‐NMR, 13C‐NMR, DEPT‐135), 2D‐NMR (COSY, NOESY, HSQC, HMBC, INADEQUATE), and HR‐MS. The solid‐state structures of 1–4, including the absolute configurations of the stereogenic carbons of the sugar moiety in 1 and 2, were established by X‐ray crystal‐structure analyses. For the newly described compounds, the trivial names sancarosides A (1) and B (2) are proposed.read more
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Comparative phytochemical studies on the roots of Polygala azizsancarii and P. peshmenii and neuroprotective activities of the two xanthones
Ihsan Calis,Eda Becer,Ayse Gül Ünlü,Zübeyde Uğurlu Aydın,Azmi Hanoğlu,H. Seda Vatansever,Ali A. Dönmez +6 more
TL;DR: In this paper , Eren et al. used polygala peshmenii roots for the isolation of four known compounds including sucrose mono-, di- and triesters, including 1,7-dihydroxy-2,3-methylenedioxy-5,6-dimethoxy-xanthone.
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Anti-oxidant and Anti-inflammatory Effects of Ethanol Extract from Polygala sibirica L. var megalopha Fr. on Lipopolysaccharide-Stimulated RAW264.7 Cells.
Cheng Yang,Jinjuan Liu +1 more
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Six New Constituents from the Fruit of Hypericum patulum and Their Anti‐Inflammatory Activity
Jingyi Xue,Wei Jiang,Li Lin,Ding-Yan Lu,Xue Ma,Yuan Lu,Ting Liu,Yidong Huang,Yong-Lin Wang,Yongjun Li +9 more
TL;DR: In this paper , four new xanthone glucosides, 3-hydroxy-2-methoxyxanthone, 4-8-dihydroxy-, 2.5-methylphenolic acid monomethyl ester, and methyl 6-hydroxanthone (6)-carboxylate (6) were isolated from the Hypericum patulum.
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Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11
Cheol Hyoung Park,Se Hoon Choi,Ja Wook Koo,Ji-Heui Seo,Hye-Sun Kim,Sung-Jin Jeong,Yoo-Hun Suh +6 more
TL;DR: The extract of dried root of Polygala tenuifolia Willdenow (BT‐11, 10 mg/kg, i.p.) could significantly reverse scopolamine‐induced cognitive impairments in rat, using a passive avoidance and a water maze test, suggesting the possibility that this extract may have some protective effects against neuronal death and cognitive impairment in Alzheimer's disease (AD), or other neurodegenerative diseases related to excitotoxicity and central cholinergic dysfunction.