Yolk sac tumors of the testis
TLDR
It is clear that yolk sac carcinoma is an entity deserving incorporation in the classification of testicular tumors as suggested by Teilum.Abstract:
The discovery of 2 yolk sac carcinomas of the mouse has established a basis in comparative pathology for the occurrence of this type of tumor in other species with yolk sacs. Grafts and tissue cultures of extra-embryonic yolk sac of the mouse have developed a clear understanding of the types of tissues one might expect in yolk sac carcinomas. The morphological appearance, age of incidence, and natural history of yolk sac carcinomas of the testis of boys have been compared to those of embryonal carcinomas. The prognosis for boys under 2 years of age with this tumor is astonishingly favorable, but that for boys over 2 years of age is desperately bad. An elderly man with the disease developed metastases soon after treatment. It is clear that yolk sac carcinoma is an entity deserving incorporation in the classification of testicular tumors as suggested by Teilum.read more
Citations
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Journal Article
Synthesis of -fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus.
TL;DR: Relatively large amounts of radioactive AFP, judged by relative intensity of AFP precipitation line on radioautography, were found in each of the liver cultures of the developing yolk sac, and AFP was observed in smaller amounts in almost all gastrointestinal tract cultures studied.
Journal ArticleDOI
Endodermal sinus tumor of the ovary: a clinical and pathologic analysis of 71 cases.
Robert J. Kurman,Henry J. Norris +1 more
TL;DR: Alpha‐fetoprotein (AFP) was identified in hyaline droplets, cell cytoplasm, and intercellular spaces of all 15 tumors examined by an immunoperoxidase technique, support the view that the neoplasm simulates yolk sac endoderm and suggests that serum radioimmunoassay might be useful to monitor response to therapy.
Book ChapterDOI
The intracisternal A-particle gene family: structure and functional aspects.
Edward L. Kuff,Kira K. Lueders +1 more
TL;DR: This chapter reviews the various aspects of research on intracisternal type A particles—expression in early development, genomic sequences as chromosomal genes and transposable elements, general molecular biology, and proteins as neoantigen in autoimmune diabetes.
Book ChapterDOI
Germ Cell Tumors of the Ovary
TL;DR: This group of ovarian neoplasms is composed of a number of histologically different tumor types and embraces all the neoplasm considered to be ultimately derived from the primitive germ cells of the embryonic gonad.
Journal ArticleDOI
A comparative study of eight cell lines derived from human testicular teratocarcinoma
Peter W. Andrews,Peter W. Andrews,D. L. Bronson,Frances J. Benham,S. Strickland,Barbara B. Knowles +5 more
TL;DR: It is proposed that human embryonal carcinoma cells, unlike those of the mouse, correspond to a preblastocyst stage of development.
References
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Journal Article
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Related Papers (5)
Endodermal sinus tumors of the ovary and testis. Comparative morphogenesis of the so-called mesonephroma ovarii (schill'r) and extraembryonic (yolk sac-allantoic) structures of the rat's placenta
Classification of endodermal sinus tumour (mesoblatoma vitellinum) and so-called "embryonal carcinoma" of the ovary
Alpha-fetoprotein and germ cell tumors: a possible role of yolk sac tumor in production of alpha-fetoprotein.
A. Talerman,W. G. Haije +1 more