Any article about immunohistochemistry of macrophage M1 and M2 in lung?
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Immunohistochemistry studies on tumor-associated macrophages (TAMs) in lung cancer reveal the complexity of macrophage phenotypes. These studies highlight the heterogeneity of TAM populations, with a predominance of M2-like macrophages in lung tumors, especially at the invasive margin. The expression of M1 and M2 gene signatures in TAMs is not mutually exclusive, as some TAMs can exhibit both profiles simultaneously. Notably, the presence of M1hot TAMs, expressing both M1 and M2-like signatures, is associated with better outcomes in early lung cancer, potentially recruiting tissue-resident memory T cells and enhancing antitumor responses. These findings underscore the importance of understanding the density, spatial distribution, and gene expression of TAM phenotypes through immunohistochemistry for prognostic evaluation in lung cancer.
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| Papers (4) | Insight |
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| The research paper discusses the immunohistochemistry of the tumor-associated macrophage M2 complex in lung adenocarcinoma, highlighting its impact on morphological changes and cancer cell interactions. | |
| The research paper explores the spatial density and distribution of M1 and M2 tumor-associated macrophages in non-small cell lung carcinoma, highlighting their prognostic value for overall survival. | |
| The research paper discusses optimized staining of macrophages in human lung tumors, focusing on pan-macrophage markers like CD68 and markers for M2 macrophages such as CD163 and CD206. | |
| ###M1hot TAMs in lung cancer display M1 and M2 gene signatures simultaneously. M1hot TAMs correlate with increased tissue-resident memory T cells infiltration and improved survival outcomes.### |
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