O
Odd Terje Brustugun
Researcher at Vestre Viken Hospital Trust
Publications - 127
Citations - 4194
Odd Terje Brustugun is an academic researcher from Vestre Viken Hospital Trust. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 24, co-authored 109 publications receiving 3250 citations. Previous affiliations of Odd Terje Brustugun include Stavanger University Hospital & Oslo University Hospital.
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Journal ArticleDOI
Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer
Jonathan Weiss,Martin L. Sos,Danila Seidel,Martin Peifer,Thomas Zander,Johannes M. Heuckmann,Roland T. Ullrich,Roopika Menon,Sebastian Maier,Alex Soltermann,Holger Moch,Patrick Wagener,Florian Fischer,Stefanie Heynck,Mirjam Koker,Jakob Schöttle,Frauke Leenders,Franziska Gabler,Ines Dabow,Silvia Querings,Lukas C. Heukamp,Hyatt Balke-Want,Sascha Ansén,Daniel Rauh,Ingelore Baessmann,Janine Altmüller,Zoe Wainer,Matthew Conron,Gavin M. Wright,Prudence A. Russell,Ben Solomon,Elisabeth Brambilla,Christian Brambilla,Philippe Lorimier,Steinar Sollberg,Odd Terje Brustugun,Walburga Engel-Riedel,Corinna Ludwig,Iver Petersen,Jörg Sänger,Joachim H. Clement,Harry J.M. Groen,Wim Timens,Hannie Sietsma,Erik Thunnissen,Egbert F. Smit,Daniëlle A.M. Heideman,Federico Cappuzzo,C. Ligorio,Stefania Damiani,Michael Hallek,Rameen Beroukhim,William Pao,Bert Klebl,Matthias Baumann,Reinhard Buettner,Karen Ernestus,Erich Stoelben,Jürgen Wolf,Peter Nürnberg,Peter Nürnberg,Sven Perner,Roman K. Thomas +62 more
TL;DR: F focal FGFR1 amplification is common in squamous cell lung cancer and associated with tumor growth and survival, suggesting that FGFR inhibitors may be a viable therapeutic option in this cohort of patients.
Journal ArticleDOI
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.
Joachim Weischenfeldt,Joachim Weischenfeldt,Taronish D. Dubash,Alexandros P. Drainas,Balca R. Mardin,Yuanyuan Chen,Adrian M. Stütz,Sebastian M. Waszak,Graziella Bosco,Ann Rita Halvorsen,Benjamin Raeder,Theocharis Efthymiopoulos,Serap Erkek,Serap Erkek,Christine Siegl,Hermann Brenner,Odd Terje Brustugun,Sebastian M. Dieter,Paul A. Northcott,Iver Petersen,Stefan M. Pfister,Martin Schneider,Steinar Solberg,Erik Thunissen,Wilko Weichert,Wilko Weichert,Thomas Zichner,Roman K. Thomas,Martin Peifer,Åslaug Helland,Claudia R. Ball,Martin Jechlinger,Rocio Sotillo,Hanno Glimm,Jan O. Korbel +34 more
TL;DR: A framework for inferring cancer-related gene overexpression resulting from CRE reorganization by integrating SCNAs, gene expression data and information on topologically associating domains (TADs) is presented and enables systematic inference of CRE rearrangements mediating dysregulation in cancer.
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Stromal CD8+ T Cell Density - A Promising Supplement to TNM staging in Non-Small Cell Lung Cancer
Tom Donnem,Sigurd M. Hald,Erna-Elise Paulsen,Elin Richardsen,Samer Al-Saad,Thomas Karsten Kilvær,Odd Terje Brustugun,Åslaug Helland,Åslaug Helland,Marius Lund-Iversen,Mette Poehl,Karen Ege Olsen,Henrik J. Ditzel,Olfred Hansen,Khalid Al-Shibli,Yury Kiselev,Torkjel M. Sandanger,Sigve Andersen,Francesco Pezzella,Roy M. Bremnes,Lill-Tove Busund +20 more
TL;DR: Stromal CD8+ TIL density has independent prognostic impact in resected NSCLC, adds prognosticimpact within each pathologic stage (pStage), and is a good candidate marker for establishing a TNM-Immunoscore.
Journal ArticleDOI
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids
Lynnette Fernandez-Cuesta,Martin Peifer,Xin Lu,Ruping Sun,Luka Ozretić,Danila Seidel,Thomas Zander,Frauke Leenders,Julie George,Christian Müller,Ilona Dahmen,Berit Pinther,Graziella Bosco,Kathryn Konrad,Janine Altmüller,Peter Nürnberg,Viktor Achter,Ulrich Lang,Peter M. Schneider,Magdalena Bogus,Alex Soltermann,Odd Terje Brustugun,Åslaug Helland,Steinar Solberg,Marius Lund-Iversen,Sascha Ansén,Erich Stoelben,Gavin M. Wright,Prudence A. Russell,Zoe Wainer,Benjamin Solomon,John K. Field,Russell Hyde,Michael P.A. Davies,Lukas C. Heukamp,Iver Petersen,Sven Perner,Christine M. Lovly,Federico Cappuzzo,William D. Travis,Jürgen Wolf,Martin Vingron,Elisabeth Brambilla,Stefan A. Haas,Reinhard Buettner,Roman K. Thomas +45 more
TL;DR: Pulmonary carcinoids are not early progenitor lesions of the highly aggressive lung neuroendocrine tumors but arise through independent cellular mechanisms, suggesting that inactivation of chromatin remodeling genes is sufficient to drive transformation in pulmonary carcinoids.
Journal ArticleDOI
SPACE – A randomized study of SBRT vs conventional fractionated radiotherapy in medically inoperable stage I NSCLC
Jan Nyman,Andreas Hallqvist,Jo-Åsmund Lund,Odd Terje Brustugun,Bengt Bergman,Per Bergström,Signe Friesland,Rolf Lewensohn,Erik Holmberg,Ingmar Lax +9 more
TL;DR: SBRT is convenient for patients and should be considered standard treatment for patients with inoperable stage I NSCLC and there was no difference in PFS and OS between SBRT and conventionally treated patients despite an imbalance of prognostic factors.