Gareth J. Thomas

TL;DR: A genome-wide search performed on two consecutive and independent panels of families with multiple affected members, using a non-parametric two-point sibling-pair linkage method, identified a putative CD-susceptibility locus on chromosome 16 which contains candidate genes which may be relevant to the pathogenic mechanism of inflammatory bowel diseases.

TL;DR: A mechanism by which mTOR controls the SASP is reported by differentially regulating the translation of the MK2 (also known as MAPKAPK2) kinase through 4EBP1.

TL;DR: A greater density of TRM cells in tumors was predictive of a better survival outcome in lung cancer, and this effect was independent of that conferred by CTL density.

TL;DR: The data suggest that an immune response, reflected by TIL levels in the primary tumour, has an important role in the improved survival seen in most HPV- positive patients, and is relevant for the clinical evaluation of HPV-positive OPSCC.

TL;DR: This study highlights the limited prognostic value of TNM staging and suggests that an SMA‐positive, myofibroblastic stroma is the strongest predictor of OSCC mortality, regardless of disease stage.