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Journal ArticleDOI
Marilia Cascalho, Jeffrey L. Platt 
11 Citations
T cells clearly help B cells to produce antibodies and acquire memory.
It was concluded that both long-lived T cells and long-lived B cells are normal residents in the bone marrow.
The effect seems to act directly on the B cells, rather than through helper T cells.
The results of both experimental approaches are consistent with a role for T cells in the regulation of responsive B cells in aging.
These results indicate that antigen-specific "resting" B cells must be activated by T cells and antigen prior to becoming responsive to cytokines.
Our studies are consistent with the view that both cognate and noncognate interactions of Ia‐restricted T cells with B cells are mediated by nonspecific factors.
Journal ArticleDOI
Marilia Cascalho, Jeffrey L. Platt 
11 Citations
These new findings show that the development and function of T cells depend on B cells independently of specific antibody production.
This phenomenon seems to involve relatively mature B cells, and a T cell marker which appears early in T cell ontogeny.
These results indicate that adherent cells possibly accompanying the T- and B-cell preparations were at a less than functional level.
Open accessJournal ArticleDOI
01 Jan 1980-Blood
57 Citations
With newer and more sensitive tests for identification of B and T cells, this observation may be recognized more frequently.