Can phytosterols modulate the liver lipidomic profile in obese murine?
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Phytosterols have been shown to modulate the liver lipidomic profile in obese murine models. Studies have demonstrated that dietary phytosterols can decrease liver fatty acids and cholesterol contents, as well as regulate the activities of lipid metabolism enzymes such as acetyl-CoA carboxylase and malic enzyme . Additionally, phytosterol consumption has been found to reduce the absorption of dietary cholesterol and alter the tissue fatty acid composition, with significant decreases in cholesterol levels observed in the liver . Furthermore, phytosterols have been shown to restore the homeostatic equilibrium of the hepatic metabolome, indicating their ability to modulate liver metabolism . These findings suggest that phytosterols can indeed have an impact on the liver lipidomic profile in obese murine models, making them a potential target for therapeutic interventions.
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4 Citations | Yes, phytosterols were found to restore the homeostatic equilibrium of the hepatic metabolome in an experimental murine colitis model. |
17 Citations | The text does not provide information specifically about the liver lipidomic profile in obese murine. |
33 Citations | Yes, phytosterols can modulate the liver lipidomic profile by decreasing acetyl-CoA carboxylase and malic enzyme activities, and reducing liver fatty acids and cholesterol contents. |
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