Chemistry of simvastatin?
Best insight from top research papers
Simvastatin is a cholesterol-lowering drug used in the treatment of cardiovascular diseases related to high cholesterol levels. It is derived from lovastatin, a secondary metabolite of fungal origin . Simvastatin inhibits the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), which is involved in cholesterol biosynthesis . It effectively lowers plasma cholesterol levels and has been reported to have therapeutic applications in regulating inflammatory and immune responses, bone turnover, neovascularization, vascular tone, and arterial pressure . Various methods have been developed for the production of simvastatin, including chemical synthesis, enzymatic synthesis, and biological synthesis . Analytical methods, such as reverse phase high-performance liquid chromatography (RP-HPLC), have been developed for the accurate and precise estimation of simvastatin and its impurities . The synthesis of simvastatin involves several steps, including the protection and deprotection of functional groups, methylation, and ring closure .
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
| The paper provides a method for preparing simvastatin, but it does not provide detailed information about the chemistry of simvastatin. | |
| The paper does not provide information about the chemistry of simvastatin. | |
Open access 01 Jan 2014 | The paper does not provide information about the chemistry of simvastatin. |
| The paper does not provide information about the chemistry of simvastatin. | |
3 Citations | The paper provides an overview of various chemical and biological methods used for the production of simvastatin, a cholesterol-lowering drug. It discusses the use of lovastatin as a starting material and highlights enzymatic synthesis of simvastatin. |
Related Questions
How to conduct HPLC-uv analyses for lovastatin?5 answersTo conduct HPLC-UV analyses for lovastatin, a suitable method involves using a reverse-phase HPLC system with specific parameters. The method typically includes a C18 column, an isocratic elution system with a mobile phase consisting of a mixture of acetonitrile and phosphate buffer, and UV detection at a specific wavelength. The flow rate, column temperature, and injection volume are crucial parameters to consider for accurate analysis. Lovastatin elutes at a specific retention time, which aids in its identification and quantification. The method should be validated following regulatory guidelines to ensure accuracy, precision, and reproducibility. By adhering to these parameters and validation criteria, a reliable HPLC-UV method can be established for the analysis of lovastatin in various samples.
How much possible of chemistry in the sports field?4 answersChemistry plays a significant role in the field of sports. It is used to improve the performance of athletes and ensure fair play. Chemical applications in sports include the use of prohibited substances by some athletes to gain an advantage over their opponents. Additionally, synthetic chemicals and composites are used in sports equipment and sports medicine. Chemistry can also be integrated into the teaching of sports in schools, allowing for discussions on social issues and the relationship between sports and scientific content. Furthermore, a learning resource has been developed that presents chemistry in the context of sports, incorporating various models of teaching and learning. By studying the chemistry of sports, it is possible to assess the chemistry and fitness of sportsmen in team sports, improving their efficiency and performance. Overall, chemistry plays a crucial role in enhancing athletic performance, ensuring fair play, and promoting scientific understanding in the field of sports.
What is the evidence for statins inducing diabetes?4 answersStatins have been associated with an increased risk of new-onset diabetes mellitus (NODM). The magnitude of this effect varies across studies. The risk of developing NODM is higher in patients with other risk factors for diabetes, those taking high-intensity statins, and older individuals. The exact mechanism behind the diabetogenic effect of statins is not yet known. However, potential mechanisms include modest weight gain and beta cell harm. Despite the increased risk of NODM, the overall benefits of statins in terms of cardiovascular disease prevention outweigh the effects on glycemic profile worsening. Patients should be informed about the slight diabetes risk associated with statin use and encouraged to make lifestyle modifications to mitigate this risk. Monitoring blood glucose levels may also be considered when starting or intensifying statin therapy.
What are the chemicals of concern in Flushing Creek?5 answersThe chemicals of concern in Flushing Creek include chlorinated solvents, metals (Cd, Zn, Al, Cu, Cr, U), arsenic, various organics (chlorinated and petroleum), nitrate, ammonium, and chloride (likely from road salt). Additionally, the levels of total organic carbon, available nitrogen, total organic matter, available phosphorus, sodium, potassium, calcium, and lead and copper (below detectable limits) were evaluated in unpolluted, polluted, and remediated mudflat samples in Bodo Creek, Nigeria. However, the specific chemicals of concern in Flushing Creek were not mentioned in the provided abstracts.
How to prepare simvastatin drugs for cell culture?5 answersSimvastatin drugs for cell culture can be prepared using various methods. One method involves micronizing simvastatin to improve its particle diameter and specific surface area, which facilitates increased in vitro dissolution rate and uniformity of dissolution rate of the simvastatin tablets. Another method involves preparing a solid dispersion of simvastatin using spray-drying technology, which results in simvastatin tablets with a slow quick-release feature in in-vitro dissolution, closer to an S-shaped dissolution curve, and higher stability. A different method involves subjecting simvastatin ammonium salt to cyclization, decoloring, and concentration to obtain a crude simvastatin product, which is then refined to obtain medical simvastatin with improved product yield, reduced impurities, and enhanced quality. Additionally, highly pure simvastatin can be prepared economically by treating lovastatin with potassium hydroxide, relactonizing the resulting compound, and acylating it with 2,2-dimethylbutyryl chloride or 2,2-dimethylbutyryl bromide.
Physical properties of simvastatin?5 answersSimvastatin is a drug used to reduce high cholesterol levels. It exists in both lactone and dihydroxyheptanoate forms, with the latter being the active form in the liver. Simvastatin can be prepared in amorphous forms using cryo-milling or melting and quench-cooling methods. These amorphous forms have different physicochemical properties and stability, with the cryo-milled form showing faster recrystallization compared to the quench-cooled form. Simvastatin can also be combined with other compounds, such as ezetimibe, to improve its physical stability. The binary amorphous ezetimibe-simvastatin system is physically stable for at least 1 year at room temperature. Simvastatin can incorporate into lipid bilayers and affect their properties, increasing membrane order in pure bilayers and membrane fluidity in bilayers containing cholesterol. Simvastatin has various pharmacological properties, including inhibiting cholesterol synthesis, regulating inflammatory and immune response, and affecting bone turnover and vascular tone. A solid medicine composition of simvastatin has been developed, which includes simvastatin, citric acid, BHA, stearic acid, and other excipients.