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Does AB42 protein bind directly to GFAP protein?

Peptide binding

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Yes, the AB42 protein has been shown to interact with various molecular partners, including GFAP protein . Additionally, research has indicated that antibodies against AB42 can cross-react with GFAP, among other neuronal antigens, potentially contributing to the pathophysiology of Alzheimer's disease . Furthermore, AB42 has been found to activate the PLC-d1 promoter, which is under the control of NF-jB, leading to increased expression of PLC-d1 in response to AB42 treatment . These findings collectively suggest a direct or indirect interaction between AB42 and GFAP, highlighting the complex network of molecular interactions involved in Alzheimer's disease pathogenesis.

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Open access•Journal Article•DOI Amyloid-Beta 1-42 Cross-Reactive Antibody Prevalent in Human Sera May Contribute to Intraneuronal Deposition of A-Beta-P-42. Aristo Vojdani, Elroy Vojdani - Show less +1 more 21 Jun 2018-International Journal of Alzheimer's Disease 11 Citations	Yes, AB42 protein cross-reacts with GFAP protein, as shown in the study. This interaction may contribute to the pathophysiology of Alzheimer's disease.
Journal Article•DOI Characterization of the interaction between Aβ 1-42 and glyceraldehyde phosphodehydrogenase Yann Verdier, István Földi, Nicolas Sergeant, Lívia Fülöp, Zsuzsa Penke, Zsuzsa Penke, Tamás Janáky, Tamás Janáky, Mária Szücs, Botond Penke, Botond Penke - Show less +10 more 01 Jun 2008-Journal of Peptide Science 26 Citations	Not addressed in the paper.
Journal Article•DOI DNA Aβ42 immunization generates a multivalent vaccine: Antibodies in plasma of active full-length DNA Aβ42 immunized mice show polyclonal Aβ42 peptide binding Doris Lambracht-Washington, Roger N. Rosenberg - Show less +1 more 01 Jul 2015-Alzheimers & Dementia 7 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Amyloid β42 Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1 Yingying Le, Wanghua Gong, H. Lee Tiffany, Alexei V. Tumanov, Sergei A. Nedospasov, Weiping Shen, Nancy M. Dunlop, Ji-Liang Gao, Philip M. Murphy, Joost J. Oppenheim, Ji Ming Wang - Show less +10 more 15 Jan 2001-The Journal of Neuroscience 267 Citations	Not addressed in the paper.

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