J
Joost J. Oppenheim
Researcher at National Institutes of Health
Publications - 463
Citations - 61853
Joost J. Oppenheim is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Chemokine & Interleukin. The author has an hindex of 130, co-authored 454 publications receiving 59601 citations. Previous affiliations of Joost J. Oppenheim include Science Applications International Corporation & University of Birmingham.
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Journal ArticleDOI
Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family
TL;DR: This review has summarized and discussed the available information concerning the regulation and structure of the genes, the structure and biochemical properties of the polypeptide products, their receptors, signal transduction, cell sources, and in vitro as well as in vivo activities of these cytokines.
Journal Article
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Philip M. Murphy,Marco Baggiolini,Israel F. Charo,Caroline A. Hébert,Richard Horuk,Kouji Matsushima,Louis H. Miller,Joost J. Oppenheim,Christine A. Power +8 more
TL;DR: A widely accepted receptor nomenclature system is described, ratified by the International Union of Pharmacology, that is facilitating clear communication in this area and updating current concepts of the biology and pharmacology of the chemokine system.
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β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
D. Yang,Oleg Chertov,S. N. Bykovskaia,Qian Chen,M. J. Buffo,J. I. Shogan,M. Anderson,J. M. Schröder,Ji Ming Wang,O. M. Z. Howard,Joost J. Oppenheim +10 more
TL;DR: In this paper, human β-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells.
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There is more than one interleukin 1.
TL;DR: The biochemical characteristics, gene cloning, cell sources, biological properties and actions of IL-1 are discussed, and reasons why this pleitotropic, nonspecific hormone-like cytokine is of considerable concern to immunologists are given.
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Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells
De Yang,Qian Chen,Albert P. Schmidt,G. Mark Anderson,Ji Ming Wang,Joseph Wooters,Joost J. Oppenheim,Oleg Chertov +7 more
TL;DR: The results suggest that, in addition to its microbicidal activity, LL-37 may contribute to innate and adaptive immunity by recruiting neutrophils, monocytes, and T cells to sites of microbial invasion by interacting with FPRL1.