Does accumulation of lilipds in cartilage cause osteoarthiritis?
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Accumulation of advanced glycation endproducts (AGEs) in articular cartilage may contribute to the development of osteoarthritis (OA) . The study found that the prevalence of OA increases with age and coincides with the accumulation of AGEs in cartilage . In vitro incubation of cartilage with glucose, ribose, or threose, which mimic the age-related increase in AGE levels, resulted in decreased proteoglycan synthesis and cartilage degradation . The chondrocyte-mediated degradation of articular cartilage also decreased with increasing age . These findings suggest that an increase in AGE levels negatively affects the turnover of cartilage, reducing its maintenance and repair capacity . Therefore, the accumulation of lipids in cartilage, specifically AGEs, may play a role in the development of OA .
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1 Citations | The provided paper does not mention anything about the accumulation of lipids in cartilage causing osteoarthritis. |
| The provided paper does not mention anything about the accumulation of lipids in cartilage causing osteoarthritis. The paper focuses on the effects of advanced glycation endproducts (AGEs) on the turnover of the extracellular matrix in human articular cartilage. | |
Open access 01 Jan 1995 | The provided paper does not mention anything about the accumulation of lipids in cartilage causing osteoarthritis. The paper focuses on the characterization of proteoglycan accumulation during the formation of cartilaginous tissue in vitro. |
| The paper does not provide information about the direct relationship between the accumulation of lipids in cartilage and osteoarthritis. The paper focuses on the association between the 4977-bp deletion of mitochondrial DNA and idiopathic osteoarthritis in knee cartilage. | |
287 Citations | The provided paper does not mention anything about the accumulation of lipids in cartilage causing osteoarthritis. The paper is about articular cartilage and osteoarthritis in general. |
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Can Overaccumulation of lipid molecules in cartilage can make the tissue more susceptible to damage ?3 answersOveraccumulation of lipid molecules in cartilage can make the tissue more susceptible to damage. Lipid metabolism plays a crucial role in the physiological activities of organs in the vertebrate body, including cartilage. Abnormal lipid metabolism has been linked to the occurrence and deterioration of cartilage diseases such as osteoarthritis and rheumatoid arthritis. In osteoarthritic articular cartilage, there is an increase in total fatty acids, including arachidonic acid, which is associated with the severity of the disease. Additionally, recent studies have highlighted the role of lipid mediators in cartilage degradation in osteoarthritis, suggesting that lipids contribute to the pathophysiology of cartilage degradation. Therefore, the overaccumulation of lipid molecules in cartilage can disrupt cartilage metabolism and contribute to tissue damage and disease progression.
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