Does COVID-19 have a direct impact on cognitive function?
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COVID-19 has been shown to have a direct impact on cognitive function. Studies have reported persistent cognitive difficulties post-COVID-19, particularly affecting attention, memory, and executive functions. Patients recovering from COVID-19 may experience cognitive impairment, with some showing no improvement in global cognitive performance even at a 2-month follow-up. Hospitalization due to COVID-19 severity has been linked to poorer attention and executive function, indicating multifaceted cognitive impairment in some cases. Additionally, factors like age, sex, anxiety, and mental health stress have been associated with post-COVID-19 cognitive status. These findings highlight the importance of monitoring cognitive function in COVID-19 patients and implementing interventions to address potential cognitive deficits.
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| Papers (4) | Insight |
|---|---|
| COVID-19 impacts cognitive function, showing increased processing speed variability in survivors. Long-COVID symptoms correlate with multifaceted cognitive impairment, especially in hospitalized individuals. | |
01 Jul 2023 | Yes, COVID-19 can impact cognitive function, especially in elderly individuals with neurocognitive disorders like mild cognitive impairment (MCI) or dementia, leading to cognitive decline and neuropsychiatric symptoms. |
18 Jun 2023 | COVID-19 can impact cognitive function, with lasting cognitive difficulties reported post-infection, especially in attention, executive function, and memory, potentially influenced by hospitalization status. |
| COVID-19 can impact cognitive function post-recovery, showing measurable neurocognitive alterations, especially in attention and working memory, as indicated by neuropsychological tests and self-reported symptoms. |
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What are the neuropsychiatric effects of COVID-19?4 answersThe neuropsychiatric effects of COVID-19 include cognitive impairment ("brain fog"), depression, anxiety, fatigue, insomnia, and mood disturbances. Other manifestations include headache, dizziness, muscle soreness, stroke, seizures, encephalitis, ataxia, myelitis, anosmia, ageusia, Guillain-Barré syndrome, and Miller Fisher syndrome. These effects can persist even after the acute phase of the infection and may be associated with a high risk of suicidal behavior. The mechanisms of these effects involve indirect factors such as cytokine storm, hypoxia, neuroinflammation, and post-infection autoimmunity, as well as possible direct damage to neurons and blood vessels by the virus. Factors such as moderate to severe COVID-19 infection, non-vaccination, and lack of social support increase the risk and severity of these neuropsychiatric manifestations. Monitoring and addressing these neuropsychiatric consequences are crucial for comprehensive COVID-19 treatment and public health management.
Long covid affect cognitive function?5 answersLong COVID can affect cognitive function. Patients with long COVID often experience cognitive deficits, including working memory, motivation, and executive functioning impairments. The dorsolateral prefrontal cortex (dlPFC) is particularly affected, and this may be due to increased levels of kynurenic acid (KYNA) and glutamate carboxypeptidase II (GCPII) in the brain. KYNA blocks neurotransmission in the dlPFC, while GCPII weakens dlPFC network connectivity and reduces neuronal firing. However, there are potential treatment options for these cognitive symptoms. N-acetyl cysteine, an antioxidant, can inhibit KYNA production, and guanfacine, an α2A-adrenoceptor agonist, can regulate dlPFC signaling and reduce inflammation. Additionally, auricular transcutaneous vagus nerve stimulation (atVNS) may be beneficial in compensating for cognitive decline and improving affective symptoms in long COVID patients. Further research is needed to understand the mechanisms underlying cognitive impairment in long COVID and to explore potential therapeutic interventions.
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What is the impact of decline of adl over time among persons living with dementia during covid?3 answersThe impact of decline in activities of daily living (ADL) over time among persons living with dementia during the COVID-19 pandemic varied across studies. One study found that COVID-19 had a significant impact on cognitive decline and accelerated decline in the Mini-Mental State Examination (MMSE) score among elderly patients with dementia. Another study reported worries of faster cognitive decline due to lockdown measures, but did not specifically measure the impact on ADL. A study in China found that confinement during the pandemic might ease cognitive and neuropsychiatric deterioration in Alzheimer's disease (AD) patients and help prevent rapid cognitive decline. A study in Italy showed a significant worsening of cognitive decline in people with dementia during the pandemic, suggesting the need for more careful assistance during future lockdowns. Finally, a study on quality of life (QoL) found that QoL did not significantly decline for persons with dementia or their family carers during the pandemic, but there was variation among subgroups.