Does curcumin prevent metastasis in cancer?
Best insight from top research papers
Curcumin, a natural phytochemical found in turmeric, has been shown to have anticancer properties and inhibit metastasis in various types of cancer, including gastrointestinal (GI) cancers and triple negative breast cancer (TNBC) . In GI cancers, curcumin has been found to inhibit migration and metastasis of cancer cells by modulating various genes and proteins involved in these processes . In TNBC, curcumin has been shown to inhibit proliferation, invasion, migration, and the formation of mammospheres, and reduce the expression of genes related to metastasis and stemness . These effects are mediated through the Hedgehog/Gli1 signaling pathway . The antimetastatic effects of curcumin have also been observed in a colon cancer mouse model, where it was found to suppress tumor growth and offer potential therapeutic benefits . Overall, these findings suggest that curcumin has the potential to prevent metastasis in cancer.
Answers from top 5 papers
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| Papers (5) | Insight |
|---|---|
| Yes, curcumin has been shown to reduce the ability of colorectal cancer cells to spread and metastasize in vitro and in mice. | |
15 Citations | Yes, curcumin inhibits the invasion and metastasis of triple negative breast cancer cells via the Hedgehog/Gli1 signaling pathway. |
12 Citations | Yes, curcumin has been shown to inhibit migration and metastasis of gastrointestinal cancers by modulating various genes and proteins. |
| Yes, curcumin prevents metastasis in colorectal cancer by activating the KEAP1/NRF2/miR-34a/b/c cascade. | |
15 Citations | Yes, curcumin has been found to inhibit the invasion and metastasis of triple negative breast cancer cells. |
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