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Does dietary ZnO effect passive immunity in suckling pigs? 

Immune system
Metallothionein
Jejunum
Ileum
Small intestine
Best insight from top research papers

Dietary ZnO supplementation has been shown to impact passive immunity in suckling pigs. Research indicates that ZnO, when combined with a bio-response modifier (BRM), can enhance neutrophil functions and reduce inflammatory cytokine responses, stimulating innate immunity earlier than ZnO or BRM alone . Additionally, studies have demonstrated that ZnO, particularly at a dose of 300 ppm, can improve growth performance and immune profiles in weaning pigs, making it a viable alternative to pharmacological ZnO supplementation . Furthermore, the use of nano-ZnO as a ZnO alternative has shown similar effects on nutrient digestibility, fecal microflora, and intestinal immune profiles in weaning pigs, suggesting its potential for promoting Zn utilization and intestinal immunity .

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Papers (5)Insight
Journal Article•DOI
Adding a bio-response modifier and zinc oxide to piglet weaner diets influences immunological responses to weaning
Ujjwal Kumar De, Reena Mukherjee, Chandan Prakash, B. H. M. Patel, Sukdeb Nandi, Umesh Dimri, Ashok Verma, Med Ram Verma 
21 Jan 2019-Animal Production Science
3 Citations
Adding ZnO to piglet diets, along with a bio-response modifier, enhances neutrophil functions and reduces inflammatory responses post-weaning, improving passive immunity in early weanling piglets.
Open access•Journal Article•DOI
Supplementation of nano-zinc in lower doses as an alternative to pharmacological doses of ZnO in weanling pigs
Taegyun Kim, Minju Kim, JunHyung Lee, Joseph Moturi, Sang-Hun Ha, Habeeb Tajudeen, JunYoung Mun, Abdolreza Hosseindoust, Byung-Jo Chae 
01 Jan 2022-Journal of Animal Science and Technology
5 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
Growth performance, immune status, gastrointestinal tract ecology, and function in nursery pigs fed enzymatically treated yeast without or with pharmacological levels of zinc
Brenda Christensen, Cuilan Zhu, Mohsen Mohammadigheisar, H. Schulze, Lee-Anne Huber, Elijah G. Kiarie 
22 Mar 2022-Journal of Animal Science
5 Citations
Dietary ZnO enhances passive immunity in nursery pigs, as indicated by increased plasma IgA concentrations, supporting improved immune status when included in the diet.
Open access•Journal Article•DOI
Changes in Diarrhea Score, Nutrient Digestibility, Zinc Utilization, Intestinal Immune Profiles, and Fecal Microbiome in Weaned Piglets by Different Forms of Zinc
Hanjin Oh, Yei-Ju Park, Jae Hyoung Cho, Minho Song, Bon-Hee Gu, Won Yun, Ji Hwan Lee, Jiseon An, Yong-Ju Kim, Jun-Soeng Lee, Sheena Kim, Hyeri Kim, Eun Sol Kim, Byoung-Kon Lee, Byeong-Woo Kim, Hyeun Bum Kim, Jin Ho Cho, Myunghoo Kim 
11 May 2021-Open Access Journal
20 Citations
Dietary ZnO affects intestinal immune profiles in weaned piglets, not specifically addressing passive immunity in suckling pigs.
Open access•Journal Article•DOI
Dietary zinc restriction affects the expression of genes related to immunity and stress response in the small intestine of pigs
Ramya Lekha Medida, Ashok K. Sharma, Yue-peng Guo, Lee J Johnston, Pedro E Urriola, Andres Gomez, Milena Saqui-Salces 
22 Nov 2022-Journal of Nutritional Science
1 Citations
Not addressed in the paper.

Related Questions

How does zinc contribute to the development of immunity in humans?5 answersZinc plays a crucial role in human immunity by influencing immune cell growth, differentiation, and function. Zinc deficiency can lead to immune system dysfunction, increasing susceptibility to infections, autoimmunity, and allergies. Studies show that zinc supplementation enhances the numbers of regulatory T cells (Tregs) while reducing Th1 and Th17 cell numbers, thus promoting immune balance. Zinc also exhibits anti-inflammatory and antioxidant properties, which are essential for a well-functioning immune system. Furthermore, research suggests that zinc supplementation can optimize immune function, potentially reducing infection risks, such as in the case of COVID-19. Overall, zinc's multifaceted roles in immune regulation highlight its significance in maintaining a robust and balanced immune response in humans.
Can zinc Enhance/improve/promote immune defence/immunity in children?4 answersZinc supplementation has been shown to enhance immune defense and improve immune function in children. It has been found to strengthen the immune system, leading to fewer and shorter respiratory tract infection episodes. Zinc deficiency is associated with a multitude of immune disorders and infectious diseases, including respiratory infections. Zinc supplementation has the potential to ameliorate infectious diseases and is considered a preventive and therapeutic agent. However, a study on pediatric patients with COVID-19 did not find a significant association between zinc supplementation and symptom reduction or ICU admission. Zinc supplementation was associated with a shorter hospital stay and a reduction in respiratory failure. Overall, zinc supplementation has the potential to enhance immune defense and improve immune function in children, but further research is needed to fully understand its effects.
What is ZnO?5 answersZinc oxide (ZnO) is a versatile material with a wide range of applications. It is a semiconductor with a bandgap of 3.37 eV at room temperature. ZnO can be synthesized in various forms, including nanoparticles, nanosheets, nanowires, and more. It exhibits unique properties such as semiconducting, piezoelectric, and pyroelectric properties. ZnO has been used as a catalyst or co-catalyst in dehydrogenative processes, leading to the production of value-added compounds. It is also utilized in various fields such as semiconductor applications, biosensors, gas sensors, solar cells, ceramics, photodetectors, and as an additive in industrial products. ZnO nanosheets, in particular, have gained attention due to their direct bandgap and strong excitonic binding energy, making them suitable for applications in piezotronics, energy storage, photodetectors, light-emitting diodes, and more. Overall, ZnO is a multifunctional nanomaterial with significant potential in various industries.
Can taking zinc supplements help to prevent colds?5 answersTaking zinc supplements may potentially reduce the duration of colds among healthy adults. However, the effects of zinc supplementation on preventing colds or reducing symptom severity are inconclusive. Further research is needed to determine the optimal dose, formulation, and duration of zinc treatment. Despite many studies and reviews, the use of zinc as a treatment for the common cold has not been definitively validated.
Can you take zinc picolinate while breastfeeding?4 answers
Is Zinc Gluconicum safe while breastfeeding?2 answers

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