Does fluoxetine has fluorescence or is indeed an derivatozation?
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Fluoxetine is a highly selective serotonin reuptake inhibitor used as an antidepressant agent. It can be detected using fluorescence detection after derivatization with specific reagents such as (R)-(+)-4-nitro-7-(2-chloroformyl-pyrrolidin-1-yl)-2,1,3-benzoxadiazole (NBD-Pro-COCl) . Another method for the determination of fluoxetine involves its derivatization with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) to form a highly fluorescent derivative that can be measured spectrofluorimetrically . Therefore, fluoxetine can exhibit fluorescence when specific derivatization reactions are performed.
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Open access•Journal Article 7 Citations | The provided paper is about the determination of atomoxetine in pharmaceutical preparations using spectrophotometric and spectrofluorimetric methods. There is no information about fluoxetine or its fluorescence in the paper. |
| The provided paper is about the spectrofluorimetric determination of paroxetine HCl (PXT) in pharmaceuticals via derivatization with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl). There is no information about fluoxetine or its fluorescence in the paper. | |
| The paper states that fluoxetine (FLX) was derivatized with a fluorescent reagent, indicating that fluoxetine itself does not have inherent fluorescence. | |
30 Citations | The paper mentions that fluoxetine (FL) and its N-demethylated metabolite norfluoxetine (NFL) were derivatized with NBD-Cl, indicating that fluoxetine itself does not have fluorescence. |
| The paper mentions that fluoxetine is derivatized with (R)-(+)-NBD-Pro-COCl for fluorescence detection, indicating that fluoxetine itself does not have inherent fluorescence. |
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