Does Glutathione delay menstruation?
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| The increased extrahepatic catabolism during fasting results in a decrease in plasma glutathione, which in turn may account for the observed increase in sinusoidal glutathione efflux with concomitant stimulation of the rate of hepatic glutathione turnover and of synthesis. | |
67 Citations | These findings indicate that factors regulating plasma glutathione concentration are complex and not simply related to dietary glutathione intake or supply of precursor amino acids. |
| The presence of glutathione S-transferases A1-1 and P1-1 in seminal fluid suggests a role in the protection against (oxidative) damage of spermatozoa, whereas glutathione may play a role in male fertility. | |
| Glutathione may ameliorate these affects. | |
216 Citations | Factors that perturb menstruation may increase a woman’s risk of other reproductive disorders. |
28 Citations | Glutathione, particularly reduced glutathione (GSH), represents a principal anitioxidant that could decrease ROS through scavenging them directly or indirectly through ascorbate-glutathione cycle or GSH peroxidases. |
| In addition, glutathione consumption via the gamma-glutamyl cycle apparently is increased during fasting. | |
81 Citations | Reduced glutathione was significantly decreased, suggesting glutathione depletion due to oxida-tive stress. |
| Glutathione levels might also be increased to compensate for the marked oxidative stress. | |
| This effect could be mediated, at least in part, by impairment in glutathione metabolism. | |
| This suggest that osmotic depletion of glutathione is not due to cellular efflux of intact glutathione. | |
35 Citations | The antioxidant action of estrogens is partially due to the stimulation of glutathione reductase. |
139 Citations | The extracellular glutathione levels were increased at that time, suggesting the efflux of glutathione. |
60 Citations | Modifications in the activity of the glutathione cycle may provide treatment options. |
Related Questions
Will glutathione stop periods?4 answersGlutathione does not stop periods. However, it plays a crucial role in various physiological processes related to oxidative stress and inflammation. Glutathione is an essential antioxidant that helps protect cells from damage caused by reactive oxygen species (ROS). Studies have shown that maintaining stable levels of glutathione is important for overall health and protection against oxidative damage. In the context of male infertility, glutathione has been identified as significant in antioxidant defenses, potentially improving sperm function. Additionally, in animals tolerant to hypoxia/anoxia, like land snails, glutathione depletion can impact redox homeostasis during stress. Therefore, while glutathione is vital for cellular protection and function, it does not have a direct effect on menstrual cycles or the cessation of periods.
How does glutathione interact with other hormones and nutrients during menstruation?5 answersGlutathione levels in breast tissue and adipose tissue increase during the midluteal phase of the menstrual cycle compared to the follicular phase. Erythrocyte glutathione peroxidase (GSH-Px) activity also shows cycle phase-related changes, with higher activity levels from the later follicular to early luteal phase. Additionally, the levels of glutathione and catalase in red blood cells are significantly higher during the phase of the menstrual cycle when estrogen levels are highest. Estradiol treatment in endometrial stromal cells leads to an increase in glutathione levels. Antiandrogens and antiestrogen can modify the activity of glutathione peroxidase and glutathione reductase. These findings suggest that glutathione interacts with sex steroid hormones, such as estrogen, during menstruation, and its levels are influenced by hormonal changes throughout the menstrual cycle.
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