Does HPV have an RNA genome?
Answers from top 10 papers
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| Papers (10) | Insight |
|---|---|
20 Citations | In the last years, the use of high-throughput sequencing technologies has revealed a number of non-coding RNA (ncRNAs), distinct from micro RNAs (miRNAs), that are deregulated in HPV-driven cancers, thus suggesting that HPV infection may affect their expression. |
| This study, which contributed the largest number of full-length HPV 6 genome sequences to date, confirmed that HPV 6 diversifies virtually equally across the entire genome by nucleotide (amino acid) exchanges in coding regions and additional nucleotide insertions/deletions in non-coding regions. | |
27 Citations | The analysis of the cloned HPV-41 nucleic acid reveals that its genome organisation is characteristic as for other papillomavirus types. |
24 Citations | The expression of HPV antisense RNA is likely to be linked to viral integration into the host genome. |
| This suggests that HPV integrates in accessible regions of the genome, preferentially genes and enhancers, which may affect the expression of target genes. | |
144 Citations | HPV may also be integrated in the host genome, further suggesting a causal role. |
37 Citations | Using this unique system RNA-seq analysis revealed extensive gene regulation of the host genome by HPV16; many of the changes have not been observed for HPV16 before. |
| Taken together, these data provide evidence that HPV has evolved a unique strategy for delivering the viral genome to the nucleus of dividing cells. | |
| Integration of the HPV genome could occur following double-strand DNA breaks that could arise during viral DNA replication. | |
45 Citations | The results strongly suggest that within-host variations of the HPV genome are primarily generated through the interaction with host cell DNA-editing enzymes and that such within-host variability is an evolutionary source of the genetic diversity of HPVs. |