Has selenium anti cancer properties?
Best insight from top research papers
Selenium has been shown to have potential anti-cancer properties. It can induce cell death in cancer cells, including under hypoxic conditions, and has been found to decrease the translocation of hypoxia-inducible factors (HIFs) from the cytosol to the nucleus . Selenium supplementation has been shown to enhance the effectiveness of standard chemotherapeutic approaches without reducing treatment efficacy, improving patients' general conditions . Selenium nanoparticles have demonstrated a good antitumor effect against various human cancer cell lines and can activate apoptosis signaling pathways leading to cancer cell death . Supra-nutritional levels of selenium, such as selenite, have shown pronounced antineoplastic effects, and their uptake is dependent on the extracellular reducing environment maintained by the Xc- cystine transporter . Selenium metabolites, such as hydrogen selenide and methylselenol, have been implicated in oxidizing sulfhydryl groups and increasing the efficacy of radiation therapy and chemotherapy .
Answers from top 5 papers
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| Papers (5) | Insight |
|---|---|
25 Citations | Yes, selenium has anti-cancer properties as it reduces cancer incidence, blocks tumor invasion and metastasis, and enhances the effects of radiation therapy and chemotherapy. |
1 Citations | The paper states that supra-nutritional levels of selenium have antineoplastic effects, but these effects are not mediated by selenoproteins. Therefore, selenium does have potential anti-cancer properties. |
| Yes, according to the results of the literature analysis in the provided paper, selenium nanoparticles exhibit a good antitumor effect against various human cancer cell lines. | |
| Yes, selenium has potential anti-cancer properties, which may be attributed to its antioxidant protection, immune surveillance enhancement, carcinogen detoxification, modulation of cell proliferation, and inhibition of angiogenesis and tumor cell invasion and migration. | |
| Yes, the paper states that selenium nanoparticles (SeNPs) show efficient anticancer properties in liver cancer cells. |
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