How biosensor on organ chip could develop the efficacy of new drug discovery?
Best insight from top research papers
Biosensors on organ chips play a crucial role in enhancing the efficacy of new drug discovery by providing a platform that mimics human physiology more accurately than traditional models. These organ-on-a-chip systems simulate organ functions and interactions, allowing for the prediction of drug responses, toxicological profiles, and pharmacokinetics in a more realistic manner. By utilizing multiplexing and nanotechnology, biosensors on organ chips can significantly improve the sensitivity and selectivity of drug-target interactions, leading to the development of miniaturized biosensors and more efficient point-of-care kits. Additionally, organ-on-a-chip technology enables the evaluation of drug efficacy in disease models, supporting the discovery of new therapies and providing insights into disease mechanisms. This innovative approach holds great promise for advancing personalized medicine and revolutionizing the drug development process.
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| Papers (5) | Insight |
|---|---|
| Biosensors on organ chips, like liver-on-a-chip, enhance drug discovery efficacy by simulating liver functions, predicting drug metabolism, and assessing toxicity in a more physiologically relevant microenvironment. | |
| Biosensors on organ chips simulate organ functions, aiding in predicting drug efficacy, toxicology, and pharmacokinetics more accurately than traditional methods, enhancing new drug development. | |
10 Citations | Organ-on-a-chip technology can enhance drug discovery efficacy by modeling lung and kidney cancer, aiding in evaluating new therapies' effectiveness and understanding disease mechanisms for improved drug development. |
| Organ-on-chip technology enhances drug discovery efficacy by mimicking human physiology more accurately than 2D models, aiding in predicting in vivo behavior and improving biosensor effectiveness. | |
| Organ-on-a-chip biosensors enhance drug discovery efficacy by mimicking human tissue, enabling understanding of disease mechanisms, drug interactions, and personalized medicine development, improving safety and efficacy predictions. |
Related Questions
How to detect the toxicity of new natural compound through organ on chip biosensor?4 answersTo detect the toxicity of a new natural compound through an organ-on-chip biosensor, advanced biosensors, including nanobiosensors, can be utilized. Organ-on-a-chip technology offers a promising approach for toxicity typing of compounds, providing a platform for targeted intervention and treatment. These microfluidic organ chips mimic human physiological conditions, enabling accurate toxicity assessment and reducing unnecessary risks to patients. By incorporating high-content readouts and fluorescent biosensors, organ-on-chip systems can analyze chemical-exposure responses effectively, aiding in the prediction of toxicity in humans. Label-free biosensors integrated with microfluidic systems have been developed for sensitive bioassays of secreted protein biomolecules from organ-on-a-chip models, facilitating real-time monitoring of drug toxicity. This comprehensive approach combines cutting-edge biosensor technology with organ-on-chip models to enhance the detection and evaluation of toxicity in new natural compounds.
What are Advantages of particle-based biosensors?5 answersParticle-based biosensors offer various advantages due to the unique properties of micro/nanoparticles. These biosensors can efficiently detect a wide range of analytes, from macromolecules to micro- or macro-particulates, including bacteria, cells, organelles, viruses, and nanoparticles. Additionally, magnetic nanoparticles (MNPs) in biosensing techniques like magnetic particle spectroscopy (MPS) enable the detection of multiple analytes simultaneously, enhancing the versatility of bioassays. Nanomaterials, such as carbon nanotubes, gold nanoparticles, and quantum dots, have been extensively studied for biosensor applications, offering high sensitivity and a quick analysis method in various fields like medical diagnostics, environmental protection, and food industries. Furthermore, nanoparticle-based biosensors, particularly using metallic NPs with optical properties like gold NPs and quantum dots, show promise in diagnosing diseases like the canine distemper virus, aiding in timely monitoring and control strategies.
What is organ-on-chip technology?5 answersOrgan-on-chip technology, also known as microphysiological systems, is a promising approach that aims to replicate human pathophysiology in vitro. It involves culturing human living cells in microfluidic devices that mimic the physiological conditions of specific organs, such as 3D structures, shear stress, and mechanical stimulation. This technology has the potential to overcome the limitations of existing animal models and improve the predictive validity of in vitro experimental models for drug development and personalized medicine. Organ-on-chip platforms can be used to study various aspects of human biology, including viral infections, pathogenesis, virus-host interactions, and drug responses. They offer a more accurate representation of human physiology and have a broad range of applications in basic biomedical research, preclinical drug development, and biomarker identification. However, there are still challenges that need to be addressed, such as gaining acceptance from regulatory agencies and pharmaceutical industries. Overall, organ-on-chip technologies hold great promise for advancing drug discovery, development, and personalized medicine.
What are the limitations of the organ on a chip?5 answersOrgan-on-a-chip (OOC) models have limitations that need to be addressed. One major challenge is the lack of online analysis methods, which hinders real-time observation of cultured cells. Another limitation is the low approval rate of nanoparticles (NPs) for clinical use, despite the success of nanomedicine in drug development. Traditional model systems offer limited clinical translation, and OOC approaches using microfluidic chips present an opportunity to overcome this limitation. Additionally, the nature of the media used in OOC models and the presence of nonvolatile buffers hamper the hyphenation of OOC with mass spectrometry (MS), preventing straightforward and online connection. Furthermore, strategies to measure mechanical tissue features directly on-chip are relatively limited, despite the importance of incorporating mechanical cues in OOC models. Overall, these limitations highlight the need for further advancements in online analysis methods, clinical translation, hyphenation with MS, and mechanical analysis techniques in OOC models.
What is the organ on a chip?4 answersOrgan-on-a-chip is an emerging technology that aims to replicate the structure, function, and physiology of human tissues on microfluidic devices. These devices mimic tissues, organs, and diseases, providing a platform for studying interactions with nanoparticles, modeling biological barriers, and investigating cancer. Organ-on-a-chip platforms can replicate higher-level anatomical, physiological, or pathological states of tissues and organs, making them valuable tools for biomedical research. These systems accurately recreate the natural physiology and mechanical forces that cells experience in the human body, allowing for the study of cancer development and spread within them. The technology has made substantial progress in mimicking tissue- and organ-level functions through advances in biomaterials, stem cell engineering, microengineering, and microfluidic technologies. Organ-on-a-chip technology has been applied in ophthalmology to model various eye diseases, study toxic effects and pharmacological activity of compounds, and improve preclinical trials of ophthalmic drugs.
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