How do maggots respond to exposure to rotenone ?
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Maggots respond to exposure to rotenone by showing locomotor impairments and a selective loss of dopaminergic neurons in the brain clusters . Additionally, rotenone exposure can increase reactive oxygen species (ROS) production in microglial cells, leading to a dose-independent augmentation of ROS production . In primary neurons, rotenone inhibits cellular bioenergetics and decreases autophagic flux, but surprisingly increases mitophagy, the autophagy of mitochondria, at 24 hours . Furthermore, non-germline allele-specific DNA methylation (ASM) regions, which are conserved in the human genome, show hypomethylation in response to rotenone exposure, potentially altering the risk of neurological disease later in life by disrupting neuronal development .
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| Papers (5) | Insight |
|---|---|
| The provided paper does not mention anything about how maggots respond to exposure to rotenone. The paper focuses on the vulnerability of DNMT1-dependent methylation regions in human cells to rotenone exposure and its potential impact on neurological disease. | |
| The provided paper does not mention anything about maggots or their response to exposure to rotenone. The paper focuses on the effects of rotenone on primary neurons and the role of autophagy in cell survival. | |
| The provided paper does not mention anything about maggots or their response to exposure to rotenone. The paper focuses on the effects of chronic exposure to rotenone on Drosophila melanogaster (fruit flies) and their dopaminergic neurons. | |
8 Citations | The provided paper does not mention anything about how maggots respond to exposure to rotenone. The paper focuses on the ventilatory responses of four marine teleosts (fish) to acute rotenone exposure. |
| The provided paper does not mention anything about maggots or their response to exposure to rotenone. The paper focuses on the response of BV-2 microglial cells to rotenone. |
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