How do you upregulate serotonin receptors?
Answers from top 10 papers
More filters
| Papers (10) | Insight |
|---|---|
Open access•Journal Article 59 Citations | Selective compounds for particular subtypes of serotonin receptors may yield selective pharmacologic effects. |
93 Citations | These effects are mediated via different serotonin (5-HT) receptors. |
54 Citations | Serotonin receptors may regulate GABAergic inhibition, influence response gain, alter spike timing, or have effects that are dependent on the level of activity. |
68 Citations | Serotonin uptake inhibitors have helped in revealing some dynamics of serotonin neurons; for example, when uptake is inhibited and extracellular serotonin concentration increases, presynaptic as well as postsynaptic receptors for serotonin are activated to a greater degree. |
40 Citations | Thus, serotonin via activating its type 2, 3 receptors, increased glutamate release at nerve terminals in some LHb neurons. |
| Future therapies may take advantage of the synergistic effect produced by the modulation of different serotonin receptors or pursue a region-specific modulation of certain receptors. | |
2 Citations | These studies demonstrate the procedures for producing and characterizing constitutively active forms of serotonin receptors, including the demonstration of inverse agonist activity of drugs on these receptors. |
| These effects of serotonin can be mediated through both the serotonin transporter and serotonin receptors. | |
| Our results show that serotonin functions as an extrasynaptic signal that independently activates multiple receptors at a distance from its release sites and identify at least six additional proteins that appear to act with serotonin receptors to mediate serotonin response. | |
| Pharmacological manipulations and receptor knockdown indicate that serotonin acts at least in part via 5-HT1A receptors. |
Related Questions
Do serotonin regulate the expression of cannabinoid receptors?5 answersSerotonin does indeed regulate the expression of cannabinoid receptors. Research indicates that serotonin receptors, particularly 5-HT2Rs, can modulate synapses by releasing endocannabinoids that activate presynaptic cannabinoid-type 1 receptors (CB1Rs). Additionally, studies have shown that non-selective cannabinoid receptor agonists can enhance the interaction between serotonin 5-HT2A receptors and dopamine D2 receptors, leading to an upregulation of 5-HT2A receptors. Furthermore, in the context of hypoxia of the neonate, cannabidiol (CBD) has been found to act on CB2–5HT1A receptor heteromers, reducing their expression in glucose/oxygen-deprived neurons and in animal models of hypoxia/ischemia, highlighting the regulatory role of cannabinoids in serotonin-related conditions.
Downregulation of 5-HT7 receptor5 answersDownregulation of the 5-HT7 receptor has been observed in various contexts. In a study by Fukuyama et al., subchronic administration of brexpiprazole, a mood-stabilizing antipsychotic, resulted in a decrease in 5-HT7 receptor expression in astrocytes and rat hypothalamus. Similarly, Reverchon et al. found that natalizumab-treated multiple sclerosis (MS) patients showed a significant increase in 5-HT7 receptor expression on T lymphocytes. In a neonatal hypoxic-ischemic (HI) injury model, Wixey et al. demonstrated a significant decrease in 5-HT7 receptor levels in the frontal cortex, thalamus, and brainstem. These findings suggest that downregulation of the 5-HT7 receptor can occur in response to pharmacological treatment and pathological conditions such as MS and neonatal HI injury.
Can you rebuild serotonin receptors?10 answers
How to increase cannabinoid receptors?10 answers
How to regenerate serotonin receptors?10 answers
How to unblock serotonin receptors?10 answers