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Angela L. M. Scott
Researcher at University of Edinburgh
Publications - 13
Citations - 487
Angela L. M. Scott is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Spinal cord & Regeneration (biology). The author has an hindex of 7, co-authored 11 publications receiving 416 citations. Previous affiliations of Angela L. M. Scott include University of British Columbia.
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Journal ArticleDOI
Molecular Evolution of Cytochrome c Oxidase Underlies High-Altitude Adaptation in the Bar-Headed Goose
Graham R. Scott,Patricia M. Schulte,Stuart Egginton,Angela L. M. Scott,Jeffrey G. Richards,William K. Milsom +5 more
TL;DR: Adaptations in mitochondrial enzyme kinetics and O(2) transport capacity may contribute to the exceptional ability of bar-headed geese to fly high.
Journal ArticleDOI
Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration
Michell M. Reimer,Anneliese Norris,Jochen Ohnmacht,Rickie Patani,Zhen Zhong,Tatyana B. Dias,Veronika Kuscha,Angela L. M. Scott,Yu-Chia Chen,S. V. Rozov,Sarah Louise Frazer,Cameron Wyatt,Shin-ichi Higashijima,E. Elizabeth Patton,Pertti Panula,Siddharthan Chandran,Thomas Becker,Catherina G. Becker +17 more
TL;DR: It is shown that descending dopaminergic projections from the brain promote motor neuron generation at the expense of V2 interneurons in the developing zebrafish spinal cord by activating the D4a receptor, which acts on the hedgehog pathway.
Journal ArticleDOI
Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish.
Antón Barreiro-Iglesias,Karolina S. Mysiak,Angela L. M. Scott,Michell M. Reimer,Yujie Yang,Catherina G. Becker,Thomas Becker +6 more
TL;DR: It is shown that, during development, diffuse serotonin promotes spinal motor neuron generation from pMN progenitor cells, leaving interneuron numbers unchanged, and serotonin selectively promotes the development and adult regeneration of motor neurons in zebrafish.
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Deafferentation and neurotrophin‐mediated intraspinal sprouting: a central role for the p75 neurotrophin receptor
TL;DR: In intact p75–/– mice, the axon density of all populations was equal to or less than that in wild‐type mice but that rhizotomy‐induced intraspinal sprouting was significantly augmented, illustrating the pivotal role of p75NTR in spinal axonal plasticity and identify it as a potential therapeutic target for spinal cord injury.
Journal ArticleDOI
Schwann cell p75NTR prevents spontaneous sensory reinnervation of the adult spinal cord
Angela L. M. Scott,Matt S. Ramer +1 more
TL;DR: It is found that nerve growth factor and neurotrophin-3-responsive axons regenerated into the spinal cord of p75(NTR) knockout mice where they made functional connections with dorsal horn neurons.