How does CTNNB1 influence in the dopaminergic system?
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CTNNB1, encoding β-catenin, plays a crucial role in the dopaminergic system. Studies show that dysregulation of CTNNB1 leads to defective dopaminergic neurogenesis, affecting brain development, motor skills, and behavior . Additionally, CTNNB1 interacts with other genes like Comt and Dtnbp1 to modulate dopaminergic signaling, impacting cognitive functions . Furthermore, CTNNB1 is implicated in neurodegenerative disorders like Parkinson's disease (PD), where it promotes neuronal survival and counteracts dopaminergic cell death in PD toxin-based models . The gene's involvement in neurodevelopmental disorders highlights its significance in synaptic plasticity, neuronal apoptosis, and neurogenesis, making it a potential therapeutic target for such conditions . Overall, CTNNB1's influence on the dopaminergic system underscores its critical role in brain development and function.
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| CTNNB1 impacts the dopaminergic system through its involvement in neurodevelopmental disorders, potentially affecting dopamine-related functions like synaptic plasticity and neuronal apoptosis. | |
8 Citations | CTNNB1 influences dopaminergic neurogenesis and dendritogenesis, potentially enhancing synaptic dopamine release, explaining the response to L-dopa in CTNNB1 deficient dystonia. |
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| Not addressed in the paper. |
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