C
Cláudia Saraiva
Researcher at University of Beira Interior
Publications - 21
Citations - 1418
Cláudia Saraiva is an academic researcher from University of Beira Interior. The author has contributed to research in topics: Neural stem cell & Neurogenesis. The author has an hindex of 10, co-authored 12 publications receiving 992 citations. Previous affiliations of Cláudia Saraiva include Lund University & Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa.
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Journal ArticleDOI
Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases.
Cláudia Saraiva,Catarina Praça,Raquel Ferreira,Tiago Santos,Lino Ferreira,Liliana Bernardino +5 more
TL;DR: The use of nanoparticle (NP) formulations able to encapsulate molecules with therapeutic value, while targeting specific transport processes in the brain vasculature, may enhance drug transport through the BBB in neurodegenerative/ischemic disorders and target relevant regions in thebrain for regenerative processes.
Journal ArticleDOI
MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease.
TL;DR: Clear evidences are provided to support the use of miR-124 NPs as a new therapeutic approach to boost endogenous brain repair mechanisms in a setting of neurodegeneration.
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Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation.
Sandra M. Rocha,Tatiana Saraiva,Ana C. Cristóvão,Raquel Ferreira,Tiago Santos,Marta Esteves,Cláudia Saraiva,Goun Je,Luísa Cortes,Jorge Valero,Gilberto Alves,Alexander L. Klibanov,Yoon Seong Kim,Liliana Bernardino +13 more
TL;DR: The results highlight the relevance of histamine in the modulation of microglial activity that ultimately may interfere with neuronal survival in the context of Parkinson’s disease (PD) and, eventually, other neurodegenerative diseases which are accompanied by microglia-induced neuroinflammation.
Journal ArticleDOI
MicroRNA: Basic concepts and implications for regeneration and repair of neurodegenerative diseases.
TL;DR: The relationship between miRNA, neurodegeneration and neurogenesis, and the benefits, outcomes and limitations of therapies using miRNA technology for neurodegnerative disorders will be discussed.
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Gold nanostructures: synthesis, properties, and neurological applications.
Iman Zare,Mohammad Tavakkoli Yaraki,Giorgio Speranza,Alireza Hassani Najafabadi,A. Shourangiz Haghighi,Amirala Bakhshian Nik,Bella B. Manshian,Cláudia Saraiva,Stefaan J. Soenen,Marcelo J. Kogan,Jee Woong Lee,Nicholas V. Apollo,Liliana Bernardino,Eyleen Araya,Dirk Mayer,Guangzhao Mao,Michael R. Hamblin +16 more
TL;DR: A broad range of neurological applications of GNS-based materials to improve clinical diagnosis and therapy includes neurotoxicity, targeted delivery of therapeutics to the central nervous system (CNS), neurochemical sensing, neuromodulation, neuroimaging, neurotherapy, tissue engineering, and neural regeneration.