F
Francesco Papaleo
Researcher at Istituto Italiano di Tecnologia
Publications - 93
Citations - 3275
Francesco Papaleo is an academic researcher from Istituto Italiano di Tecnologia. The author has contributed to research in topics: Prefrontal cortex & Schizophrenia. The author has an hindex of 29, co-authored 81 publications receiving 2604 citations. Previous affiliations of Francesco Papaleo include University of Padua & Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.
Papers
More filters
Journal ArticleDOI
Genetic Dissection of the Role of Catechol-O-Methyltransferase in Cognition and Stress Reactivity in Mice
Francesco Papaleo,Jacqueline N. Crawley,Jian Song,Barbara K. Lipska,Jim Pickel,Daniel R. Weinberger,Jingshan Chen +6 more
TL;DR: A critical role for the COMT gene is indicated in an apparent evolutionary trade-off between cognitive and affective functions and in the involvement of PFC CaMK pathways in COMT-regulated cognitive function and adaptive stress responses.
Journal ArticleDOI
Chronic and Acute Intranasal Oxytocin Produce Divergent Social Effects in Mice
Huiping Huang,Caterina Michetti,Marta Busnelli,Francesca Managò,Sara Sannino,Diego Scheggia,Luca Giancardo,Diego Sona,Vittorio Murino,Bice Chini,Maria Luisa Scattoni,Francesco Papaleo +11 more
TL;DR: Chronic intranasal OXT treatment in wild-type C57BL/6J adult mice produced a selective reduction of social behaviors concomitant to a reduction of the OXT receptors throughout the brain, indicating that a prolonged over-stimulation of a ‘healthy’ oxytocinergic brain system results in specific detrimental effects in social behaviors.
Journal ArticleDOI
Role of dysbindin in dopamine receptor trafficking and cortical GABA function
Yuanyuan Ji,Feng Yang,Francesco Papaleo,Huai-Xing Wang,Wen-Jun Gao,Daniel R. Weinberger,Bai Lu +6 more
TL;DR: It is suggested that dysbindin regulates PFC function by facilitating D2-mediated modulation of GABAergic function.
Journal ArticleDOI
Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways
Francesco Papaleo,Feng Yang,S. Garcia,Jingshan Chen,Bai Lu,Jacqueline N. Crawley,D.R. Weinberger +6 more
TL;DR: Dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components is elucidated, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis.
Journal ArticleDOI
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy
Amanda J. Law,Yanhong Wang,Yoshitatsu Sei,Patricio O'Donnell,Patrick T. Piantadosi,Francesco Papaleo,Richard E. Straub,Richard E. Straub,Wenwei Huang,Craig J. Thomas,Radhakrishna Vakkalanka,Aaron D. Besterman,Aaron D. Besterman,Barbara K. Lipska,Thomas M. Hyde,Paul Harrison,Joel E. Kleinman,Daniel R. Weinberger +17 more
TL;DR: The data provide insight into a mechanism of ErbB 4 association with schizophrenia; reveal a previously unidentified biological and disease link between NRG1-ErbB4, p110δ, and AKT; and suggest that p 110δ is a previously undescribed therapeutic target for the treatment of psychiatric disorders.